Yang Chai

CSA 105 - HSC 9062
Phone: (323) 442-3480
Fax: (323) 442-2981
ychai@usc.edu
website: chailab.usc.edu

Yang Chai, D.D.S., Ph.D.

George and MaryLou Boone Professor of Craniofacial Molecular Biology, Ostrow School of Dentistry of USC

Director, Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of USC

Associate Dean of Research, Ostrow School of Dentistry of USC

  • School of Stomatology, Peking University, Beijing, China
    D.M.D. (MB)
    1979-1984
    Stomatology

  • School of Stomatology, Peking University, Beijing, China
    Residency
    1984-1986
    Oral-Maxillofacial Surgery

  • University of Southern California, Los Angeles, California
    Ph.D.
    1987-1991
    Craniofacial Biology

  • University of Southern California, Los Angeles, California
    Postdoc
    1991-1994
    Craniofacial Molecular Biology

  • University of Southern California, Los Angeles, California
    D.D.S.
    1994-1996
    Dentistry

  • 2009 - Present - Associate Dean of Research - Ostrow School of Dentistry of USC
  • 2007 - Present - Director, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 2006 - Present - George and MaryLou Boone Professor of Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 2004 - 2009 - Chair, Division of Craniofacial Sciences and Therapeutics - Ostrow School of Dentistry of USC
  • 2002 - 2006 - Associate Professor, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 1996 - 2002 - Assistant Professor, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 1991 - Present - Course Director, Head and Neck Anatomy,Human Anatomy - Ostrow School of Dentistry of USC
  • 1991 - 1996 - Research Assistant Professor, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 1991 - 1994 - Postdoctoral Fellow, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC
  • 1987 - 1991 - Research Associate, Graduate Program in Craniofacial Biology - Ostrow School of Dentistry of USC
  • 1984 - 1986 - Teaching Faculty and Surgical Resident, Department of Oral-Maxi1lofacial Surgery - School of Stomatology, Peking University, Beijing, China
  • 2013 - Chair of the Board of Scientific Counselors, NIDCR, NIH
  • 2011 - IADR Distinguished Scientist Award - Craniofacial Biology Research Award
  • 2010-present - Editorial Board, Journal of Bone and Mineral Research
  • 2010 - NIH MERIT Award
  • 2010 - American Association for the Advancement of Sciences (AAAS) Elected Fellow
  • 2008-2012 - Member of the Board of Scientific Counselors, NIDCR, NIH
  • 2007-present - Editorial Board DEVELOPMENTAL BIOLOGY, JBMR
  • 2006-present - Editorial Board, The Chinese Journal of Dental Research
  • 2004-2008 - Regular member of SBDD study section CSR NIH.
  • 2004, 2006 - Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
  • 2002-present - NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK
  • 2001-2003 - Award of Excellence in Teaching, University of Southern California
  • 1997, 2007 - James H. Zumberge Faculty Research and Innovation Award, University of Southern California
  • 1997 - Annual Excellence in Teaching Award, University of Southern California
  • 1996 - OKU Scholarship award for outstanding academic performance
  • 1996 - Special Recognition by the Dean for outstanding service and contribution to the University of Southern California
  • 1995 - Annual Teaching Award, University of Southern California, School of Dentistry
  • 1991 - PHI KAPPA PHI, All-University Honor Society, University of Southern California, (GPA 4.0)
  • 1990 - Certificate for Outstanding Academic Achievement, University of Southern California

Research on Functional Genomics, Image Analysis and Rescue of Cleft Palate - Grant #U01 DE020065

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: September 21, 2009 to April 30, 2015
  • Goal: The goal of this project is to generate tremendous resources for the FaceBase Consortium and also offer opportunities for extensive collaborations for future translational research on craniofacial birth defects.

Molecular Regulatory Mechanism of Tongue Morphogenesis - Grant #R01 DE014078

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: July 1, 2009 to June 30, 2015
  • Goal: The goals of this project are to test the hypothesis that TGF-b signaling controls the fate of CNC as well as mesoderm-derived cells and regulates tissue-tissue interaction during tongue development.

TGF-beta signaling and craniofacial morphogenesis - Grant #R37 DE012711

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: January 1,1999 to June 30, 2019
  • Goal: The project is to understand the molecular and cellular mechanism that is critical for regulating palatal fusion during craniofacial morphogenesis.

Interdisciplinary New Faculty Recruitment in Craniofacial Development - Grant #P30 DE020750

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: September 17, 2009 to August 31, 2013
  • Goal: This project is directed at recruiting junior faculty members whose research interests are complementary to our goal of enhancing our understanding of the polydisciplinary events shaping craniofacial morphogenesis, their malformations and the use of stem cell biology for their regeneration.

The Molecular Regulatory Mechanism of Calvarial Morphogenesis - Grant #R01 DE017007

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: September 1, 2005 to August 31, 2012
  • Goal: This is a project designed to investigate the signaling network involved in regulating frontal bone development and malformation.

Msx1 Signaling and Craniofacial Morphogenesis - Grant ##6-FY02-137 & #6-FY05-67

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: March of Dimes Birth Defects Foundation
  • Period: June 1, 2002 to May 31, 2009
  • Goal: This project is to investigate the function of homeobox gene Msx1 in regulating the fate of cranial neural crest-derived ectomesenchyme during craniofacial morphogenesis.

Craniofacial Morphogenesis and Tissue Regeneration - Grant #R13 DE015738

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: Jan, 1, 2004 to Dec. 31, 2006
  • Goal: The goal of this project is to support the Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration.

Global Analysis of TGF-beta Signaling-Mediated Cell Cycle Regulators during Palatogenesis

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: James H. Zumberge Faculty Research & Innovation Fund
  • Period: March 1, 2007 to June 30, 2009
  • Goal: This project is designed to explore the dynamic gene expression profiles during palate fusion.

The Molecular Regulatory Mechanism of Tooth Root Development - Grant #5 R01 DE022503

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: July 19, 2012 to June 30, 2017
  • Goal: This study will provide a better understanding of the molecular regulatory mechanism of root development. The knowledge gained from this study will serve as the foundation for stem cell mediated tooth regeneration.

Integrated Research of Functional Genomics and Craniofacial Morphogenesis - Grant #5 U01 DE024421

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: May 12, 2014 to June 30, 2019
  • Goal: In this FaceBase spoke project, we will investigate the development of the mandible and maxilla through gene expression profiling and quantitative 3D dynamic imaging analyses, as well as test how manipulating specific genes can prevent and rescue mandible defects. Our study will generate important resources for the research community, inform clinical diagnosis and provide potential approaches to prevent or rescue craniofacial malformations.

Facebase 2 Coordinating Center - Grant #5 U01 DE024449

  • Principal Investigator: Carl Kesselman, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: May 16, 2014 to June 30, 2019
  • Goal: The major goals of this project are to create FaceBase2 hub infrastructure driven by principles of ease of use and user centered design to manage data throughout its lifecycle; to provide tools within the hub that accelerate craniofacial research by enabling data annotation, integration and analysis; and to promote use and collaboration across the FaceBase research network.

Center for Dental, Oral and Craniofacial Tissue Organ Regeneration (C-DOCTOR) - Grant #1 R34 DE025575

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: September 1, 2015 to August 31, 2016
  • Goal: This C-DOCTOR project will provide comprehensive services to meet patient needs for tissue regeneration by establishing well-defined procedures for successful experimental design, large animal models, product validation, manufacturing scale-up, regulatory approval, clinical testing, and implementation.

Molecular Regulatory Mechanism of Mesenchymal Stem Cells in Adult Mouse Incisors - Grant #5 R01 DE025221

  • Principal Investigator: Yang Chai, DDS, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: May 1, 2016 to April 30, 2021
  • Goal: The goal of this project to provide important knowledge of the signaling network that regulates the transition from MSCs to TA cells in maintaining tissue homeostasis and will serve as the foundation for future studies in MSC biology and stem cell-mediated tissue regeneration.

Molecular and Cellular Basis of Craniosynostosis - Grant #5 R01DE026339

  • Principal Investigator: Yang Chai, DDS, PhD, Gage Crump, PhD, Robert Maxson, PhD
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: July 1, 2016 to June 30, 2021
  • Goal: The goal of this project is to investigate the role of stem cell regulation in cranial suture development and maintenance, and its pathophysiology in craniosynostosis.

Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR) - Grant #1 U24 DE026914

  • Principal Investigator: Yang Chai, DDS, PhD with Multiple PIs
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: March 1, 2017 to February 29, 2020
  • Goal: The overall goal of this U24 is to operationalize the Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration (C-DOCTOR). Through an integrated series of collaborative planning activities funded during Stage I, eight renowned centers of translational research excellence - UCSF, USC, UCLA, UCB, UCD, UCSD, CoH, and Stanford - have partnered to form a public-private consortium focused on accelerating promising tissue engineering/regenerative medicine therapies for dental, oral, and craniofacial (DOC) tissue to human clinical trials.
  1. Sugii H, Grimaldi A, Li J, Parada C, Vu-Ho T, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y. (2017) Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development. 2017 Oct 5. pii: dev.155176. doi: 10.1242/dev.155176. [Epub ahead of print] PubMed PMID: 28982687.

  2. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. (2017) Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20;7(1):3876. doi: 10.1038/s41598-017-03614-y. PubMed PMID: 28634413; PubMed Central PMCID: PMC5478660.

  3. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. (2017) BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jul 15;144(14):2560-2569. doi: 10.1242/dev.150136. Epub 2017 Jun 2. PubMed PMID: 28576771.

  4. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W 3rd, Sanchez-Lara PA, Chai Y. (2017) Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 Jan 9. pii: ddx002. doi: 10.1093/hmg/ddx002. [Epub ahead of print] PubMed PMID: 28069795.

  5. Li J, Parada C, Chai Y. (2017) Cellular and molecular mechanisms of tooth root development. Development. 2017 Feb 1;144(3):374-384. doi: 10.1242/dev.137216. Review. PubMed PMID: 28143844; PubMed Central PMCID: PMC5341797.

  6. Park S, Zhao H, Urata M, Chai Y. (2016) Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 Dec 1;25(23):1801-1807. PubMed PMID: 27762665; PubMed Central PMCID: PMC5124738.

  7. Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. (2016) Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15;143(22):4115-4126. PubMed PMID: 27660324; PubMed Central PMCID: PMC5117215.

  8. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. (2016) Generation and characterization of tamoxifen-inducible Pax9-CreER Knock-In Mice using CrispR/Cas9. Genesis. 2016 Sep;54(9):490-6. doi: 10.1002/dvg.22956. Epub 2016 Jul 26. PubMed PMID: 27381449; PubMed Central PMCID: PMC5021577.

  9. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J; FaceBase Consortium, Chai Y. (2016) The FaceBase Consortium: A Comprehensive Resource for Craniofacial Researchers. Development. 2016 Jul 15;143(14):2677-88. doi: 10.1242/dev.135434. Epub 2016 Jun 10. PubMed PMID: 27287806; PubMed Central PMCID: PMC4958338.

  10. Burg ML, Chai Y, Yao CA, Magee W 3rd, Figueiredo JC. (2016) Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016 Mar 1;7:67. doi: 10.3389/fphys.2016.00067. eCollection 2016. Review. PubMed PMID: 26973535; PubMed Central PMCID: PMC4771933.

  11. Grimaldi A, Parada C, Chai Y. (2015) A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015 Dec 15;10(12):e0145018. doi:10.1371/journal.pone.0145018. eCollection 2015. PubMed PMID: 26671681; PubMed Central PMCID: PMC4687642.

  12. Parada C, Chai Y. (2015) Mandible and Tongue Development. Curr Top Dev Biol.2015;115:31-58. doi: 10.1016/bs.ctdb.2015.07.023. Epub 2015 Oct 1. PubMed PMID:26589920; PubMed Central PMCID: PMC4869709.

  13. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. (2015) Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 1;142(21):3734-45. doi:10.1242/dev.125328. Epub 2015 Sep 22. PubMed PMID: 26395480; PubMed Central PMCID: PMC4647211.

  14. Zhao H, Chai Y. (2015) Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov;94(11):1495-501. doi: 10.1177/0022034515603972. Epub 2015 Sep 8. Review. PubMed PMID: 26350960; PubMed Central PMCID: PMC4622324.

  15. Liu Y, Feng JF, Li JY, Zhao Hu, Ho TV, Chai Y. (2015) An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development. Development. 2015 Oct 1;142(19):3374-82. doi:10.1242/dev.127068. Epub 2015 Aug 20. PubMed PMID: 26293299; PubMed Central PMCID: PMC4631759.

  16. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang SL, Chai Y. (2015) BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth. Dev Cell. 2015 Apr 20;33(2):125-35. doi:10.1016/j.devcel.2015.02.021. Epub 2015 Apr 9. PubMed PMID: 25865348; PubMed Central PMCID: PMC4406846.

  17. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr;17(4):386-96. doi: 10.1038/ncb3139. Epub 2015 Mar 23. PubMed PMID: 25799059; PubMed Central PMCID: PMC4380556.

  18. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. (2015) Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17;459(4):706-12. doi: 10.1016/j.bbrc.2015.03.014. Epub 2015 Mar 11. PubMed PMID:25770424.

  19. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. (2015) Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15;400(2):180-90. doi: 10.1016/j.ydbio.2015.02.010. Epub 2015 Feb 23. PubMed PMID: 25722190; PubMed Central PMCID: PMC4385433.

  20. Zhong Z, Zhao H, Mayo J, Chai Y. (2015) Different Requirements for Wnt Signaling in Tongue Myogenic Subpopulations. J Dent Res. 2015 Mar;94(3):421-9. doi:10.1177/0022034514566030. Epub 2015 Jan 9. PubMed PMID: 25576472; PubMed Central PMCID: PMC4336158.

  21. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. (2014) A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep;42(9):637-44. PubMed PMID: 25265730.

  22. Han A, Zhao H, Li J, Pelikan R, Chai Y. (2014) ALK5-Mediated Transforming Growth Factor β Signaling in Neural Crest Cells Controls Craniofacial Muscle Development via Tissue-Tissue Interactions. Mol Cell Biol. 2014 Aug 15;34(16):3120-31. doi:10.1128/MCB.00623-14. Epub 2014 Jun 9. PubMed PMID: 24912677; PubMed Central PMCID: PMC4135603.

  23. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. (2014) Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6;14(2):160-73. doi:10.1016/j.stem.2013.12.013. PubMed PMID: 24506883; PubMed Central PMCID:PMC3951379.

  24. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. (2014) TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb;141(4):909-17. doi: 10.1242/dev.103093. PubMed PMID: 24496627; PubMed Central PMCID: PMC3912833.

  25. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. (2014) Modulation of Lipid Metabolic Defects Rescues Cleft Palate in Tgfbr2 Mutant Mice. Hum Mol Genet. 2014 Jan 1;23(1):182-93. doi: 10.1093/hmg/ddt410. Epub 2013 Aug 23. PubMed PMID: 23975680; PubMed Central PMCID: PMC3857953.

  26. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. (2013) Non-canonical transforming growth factor beta (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11;288(41):29760-70. doi:10.1074/jbc.M113.493551. Epub 2013 Aug 15. PubMed PMID: 23950180; PubMed Central PMCID: PMC3795273.

  27. Xu X, Chen C, Akiyama K, Chai Y, Le AD, Wang Z, Shi S. (2013) Gingivae Contain Neural-crest- and Mesoderm-derived Mesenchymal Stem Cells. J Dent Res. 2013 Sep;92(9):825-32. doi: 10.1177/0022034513497961. Epub 2013 Jul 18. PubMed PMID:23867762; PubMed Central PMCID: PMC3744273

  28. Parada C, Li J, Iwata J, Suzuki A, Chai Y. (2013) CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development. Mol Cell Biol. 2013 Sep;33(17):3482-93. doi:10.1128/MCB.00615-13. Epub 2013 Jul 1. PubMed PMID: 23816882; PubMed Central PMCID: PMC3753855.

  29. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. (2013) Smad2 and MRTFB Cooperatively Regulate Vascular Smooth Muscle Differentiation from Neural Crest Cells. Circ Res. 2013 Sep 27;113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921.Epub 2013 Jul 1. PubMed PMID: 23817199; PubMed Central PMCID: PMC3837448.

  30. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. (2013) Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation. PLoS One. 2013 Apr 17;8(4):e61653. doi: 10.1371/journal.pone.0061653. Print 2013. PubMed PMID: 23613893; PubMed Central PMCID: PMC3629100.

  31. Song Z, Liu C, Iwata J*, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. (2013) Mice with tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50. doi: 10.1074/jbc.M112.432286. Epub 2013 Mar 4. PubMed PMID: 23460641; PubMed Central PMCID: PMC3624426.

  32. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. (2013) Identification of candidate downstream targets of TGF-bate signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr;114(4):796-807. doi:10.1002/jcb.24417. PubMed PMID: 23060211; PubMed Central PMCID: PMC3777336.

  33. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. (2013) Smad4-Irf6 genetic interaction and TGF-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar;140(6):1220-30. doi: 10.1242/dev.089615. Epub 2013 Feb 13. PubMed PMID: 23406900; PubMed Central PMCID: PMC3585659.

  34. Huang XF, Chai Y. (2012) Molecular Regulatory Mechanism of Tooth Root Development. Int J Oral Sci. 2012 Dec;4(4):177-81. doi: 10.1038/ijos.2012.61. Epub 2012 Dec 7.PubMed PMID: 23222990; PubMed Central PMCID: PMC3633063.

  35. Parada C, Chai Y. (2012) Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012;16:60-70. doi: 10.1159/000337617. Epub 2012 Jun 25. Review. PubMed PMID: 22759670; PubMed Central PMCID: PMC3661199.

  36. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. (2012) A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May;40(5):433-6, 438-9. PubMed PMID: 22685951.

  37. Han D, Zhao H, Parada C, Hacia JG, Bringas, Jr. P, Chai Y. (2012) A TGF-beta-Smad4-FGF6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development Development. 2012 May;139(9):1640-50. Epub 2012 Mar 21.PubMed PMID: 22438570; PubMed Central PMCID: PMC3317969.

  38. Iwata J, Hacia J, Suzuki A, Sanchez-Lara P, Urata M, Chai Y. (2012) Modulation of non-canonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar 1;122(3):873-85. doi: 10.1172/JCI61498. Epub 2012 Feb 13. PubMed PMID: 22326956; PubMed Central PMCID: PMC3287237.

  39. Parada C, Han D, Chai Y. (2012) Molecular and Cellular Regulatory Mechanisms of Tongue Myogenesis. J Dent Res. 2012 Jun;91(6):528-35. Epub 2012 Jan 4. Review.PubMed PMID: 22219210; PubMed Central PMCID: PMC3348065.

  40. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor beta (TGFb) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20;287(4):2353-63. Epub 2011 Nov 28. PubMed PMID: 22123828;PubMed Central PMCID: PMC3268397.

  41. Huang XF, Yokota T, Iwata J, Chai Y. (2011) TGF-beta mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res. 2011 Aug;90(8):981-7. Epub 2011 May 18. PubMed PMID: 21593251; PubMed Central PMCID: PMC3170164.

  42. Hung Y, Huang X, Chai Y. (2011) Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May;39(5):321-4. PubMed PMID: 21721476.

  43. Li J, Huang X, Xu X, Mayo J, Bringas P Jr, Jiang R, Wang S, Chai Y. (2011) SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May;138(10):1977-89. Epub 2011 Apr 13. PubMed PMID: 21490069; PubMed Central PMCID: PMC3082303.

  44. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Iwata J, Marazita ML, Murray JC, Murray S, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. (2011) The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15;355(2):175-82. doi: 10.1016/j.ydbio.2011.02.033. Epub 2011 Mar 31. PubMed PMID: 21458441; PubMed Central PMCID: PMC3440302.

  45. Zhao H, Li S, Han D, Kaartinen V, Chai Y. (2011) Alk5-mediated TGF-beta signaling acts upstream of FGF10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol.2011 May;31(10):2079-89. Epub 2011 Mar 14. PubMed PMID: 21402782; PubMed Central PMCID: PMC3133354.

  46. Iwata J, Parada C, Chai Y. (2011) The mechanism of TGF-beta signaling during palatogenesis. Oral Dis. 2011 Nov;17(8):733-44. doi:10.1111/j.1601-0825.2011.01806.x. Epub 2011 Mar 13. Review. PubMed PMID:21395922; PubMed Central PMCID: PMC3329177.

  47. Chung IH, Han J, Iwata J, Chai Y. (2010) Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov;48(11):645-55. doi:10.1002/dvg.20671. Epub 2010 Nov 2. PubMed PMID: 20824629; PubMed Central PMCID: PMC2995851.

  48. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. (2010) Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov;28(11):2027-40. doi: 10.1002/stem.525. PubMed PMID: 20848654; PubMed Central PMCID: PMC3087810.

  49. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. (2010) Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21. Epub 2010 Aug 19. PubMed PMID: 20727875; PubMed Central PMCID: PMC3010875.

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