Stephen Yen

CSA A-207 - HSC 9062
Phone: (323) 442-1747
Fax: (323) 442-2981

Stephen Yen, D.M.D., Ph.D.

Associate Professor of Dentistry (Clinical Scholar), Endodontics, OMS & Orthodontics, Basic Sciences, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

  • Harvard College

  • Harvard School of Dental Medicine

  • University of Southern California
    Craniofacial Biology

  • University of Southern California

  • 2011 - - Fellowship Director - American Dental Association Accreditation of Craniofacial Orthodontic Fellowship
  • 2006 - present - Associate Professor of Dentistry (Clinical Scholar), Endodontics, OMS & Orthodontics, Basic Sciences - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2004 - 2006 - Director of Fellowship in Craniofacial Orthodontics - Childrens Hospital Los Angeles
  • 1996 - 2006 - Assistant Professor in Dentistry - University of Southern California, Los Angeles, CA-Orthodontics, Oral surgery, Basic Sciences
  • 1993 - Consultant for California Children Services - State of California
  • 1993 - - Clinical Assistant Professor of Orthodontics - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1992 - present - Orthodontic Attending, Oral and Maxillofacial Surgery Dept. - Ostrow School of Dentistry of USC and USC/LAC Hospital, Los Angeles
  • 1991 - present - Orthodontic Attending, Craniofacial Team - Children's Hospital Los Angeles
  • 1987 - 1992 - Graduate student, Craniofacial Biology - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1985 - 1987 - Clinical Lecturer in Children's Dentistry - Hong Kong University
  • 1985 - 1987 - Clinical Lecturer in Dentistry - Sun Yat-Sen Medical College, Guangzhou, China
  • 1980 - 1985 - Research Track in FiveYear Dental Program - Harvard School of Dental Medicine
  • 2012 - Visiting Faculty, National University of Singapore
  • 2011 - Keynote Speaker, Brazilian Orthodontic Association(ABOR), guest interview, Orthodontic Press J.
  • 2009 - Keynote speaker , Angle Society of Southern Califonia
  • 2009 - Guest Faculty, International Congress of Cleft lip and Palate, San Francisco, CA
  • 2005 - American Board of Orthodontics, Cum Laude in Research, Harvard School of Dental Medicine, Cum Laude, Harvard College
  • 1993 - Written examination passed, American Board of Orthodontics
  • 1977 - Harvard Scholarship for Academic Excellence

Completed Grants

Clinical Effectiveness of Late Maxillary Protraction for Cleftlip and Palate - Grant #5 U01 DE022937

  • Principal Investigator: Stephen L-K Yen, D.M.D., Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/20/2013-05/31/2021
  • Goal: To provide non-surgical and non-invasive alternatives to treatment for the skeletal underbite without taking away surgical options and to reduce the cost of care associated with cleft lip and palate.

Late Maxillary Protraction for Cleft Lip and Palate - Grant #R21 DE019164

  • Principal Investigator: Stephen L-K Yen, D.M.D., Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/25/2009-08/31/2012
  • Goal: This planning grant will serve to plan a randomized control trial among five research centers to test whether adolescent maxillary protraction can be a non-surgical alternative to orthognathic surgery as a treatment for a skeletal underbite in the cleft lip and palate patient population.
  1. Lee MK, Yen SL, Allareddy V. (2018) Hospitalization Outcomes of Cleft Lip Repair in Neonates Across the United States. Cleft Palate Craniofac J. 2018 Apr;55(4):528-535. doi: 10.1177/1055665617726531. Epub 2017 Dec 27. PubMed PMID: 29554443.

  2. Liang F, Yen SL, Imahiyerobo T, Sanborn L, Yen L, Yen D, Nazarian S, Jedrzejewski B, Urata M, Hammoudeh J. (2017) Three-Dimensional Cone Beam Computed Tomography Volumetric Outcomes of rhBMP-2/Demineralized Bone Matrix versus Iliac Crest Bone Graft for Alveolar Cleft Reconstruction. Plast Reconstr Surg. 2017 Oct;140(4):767-774. doi: 10.1097/PRS.0000000000003686. PubMed PMID: 28953728.

  3. Hammoudeh JA, Fahradyan A, Gould DJ, Liang F, Imahiyerobo T, Urbinelli L, Nguyen JT, Magee W 3rd, Yen S, Urata MM. (2017) A Comparative Analysis of Recombinant Human Bone Morphogenetic Protein-2 with a Demineralized Bone Matrix versus Iliac Crest Bone Graft for Secondary Alveolar Bone Grafts in Patients with Cleft Lip and Palate: Review of 501 Cases. Plast Reconstr Surg. 2017 Aug;140(2):318e-325e. doi: 10.1097/PRS.0000000000003519. PubMed PMID: 28746285.

  4. Lee MK, Lane C, Azeredo F, Landsberger M, Kapadia H, Sheller B, Yen SL. (2017) Clinical effectiveness of late maxillary protraction in cleft lip and palate: A methods paper. Orthod Craniofac Res. 2017 Jun;20 Suppl 1:129-133. doi:10.1111/ocr.12182. PubMed PMID: 28643931; PubMed Central PMCID: PMC5484074.

  5. Yen SL. (2016) A Comparison between Osteotomy and Corticotomy-Assisted Tooth Movement. Front Oral Biol. 2016;18:124-9. doi: 10.1159/000351907. Epub 2015 Nov 24. PubMed PMID: 26599126.

  6. Yamazaki K, Eng C, Kuznetsov SA, Reinisch J, Yamashita DD, Walker J, Cheung C, Robey PG, Yen SL. (2015) Missense mutation in the PTEN promoter of a patient with hemifacial hyperplasia. Bonekey Rep. 2015 Jul 29;4:654. doi: 10.1038/bonekey.2015.21. eCollection 2015. PubMed PMID: 26229595; PubMed Central PMCID: PMC4520444.

  7. Guo J, Wang Q, Wai D, Zhang QZ, Shi SH, Le AD, Shi ST, Yen SL. (2015) Visible red and infrared light alters gene expression in human marrow stromal fibroblast cells. Orthod Craniofac Res. 2015 Apr;18 Suppl 1:50-61. doi: 10.1111/ocr.12081. PubMed PMID: 25865533; PubMed Central PMCID: PMC4408556.

  8. Garib DG, Garcia LC, Pereira V, Lauris RC, Yen S. (2014) A rapid maxillary expander with differential opening. J Clin Orthod. 2014 Jul;48(7):430-5. PubMed PMID:25127383.

  9. McIlvaine E, Borzabadi-Farahani A, Lane CJ, Azen SP, Yen SL. (2014) Apriori feasibility testing of randomized clinical trial design in patients with cleft deformities and Class III malocclusion. Int J Pediatr Otorhinolaryngol. 2014 May;78(5):725-30. doi: 10.1016/j.ijporl.2014.01.006. Epub 2014 Feb 12. PubMed PMID: 24630053; PubMed Central PMCID: PMC4336545.

  10. Borzabadi-Farahani A, Lane CJ, Yen SL. (2014) Late maxillary protraction in patients with unilateral cleft lip and palate: a retrospective study. Cleft Palate Craniofac J. 2014 Jan;51(1):e1-e10. doi: 10.1597/12-099. Epub 2012 Dec 13. PubMed PMID: 23237432.

  11. Chung EH, Borzabadi-Farahani A, Yen SL. (2013) Clinicians and laypeople assessment of facial attractiveness in patients with cleft lip and palate treated with LeFort I surgery or late maxillary protraction. Int J Pediatr Otorhinolaryngol. 2013 Sep;77(9):1446-50. doi: 10.1016/j.ijporl.2013.05.042. Epub 2013 Jul 18. PubMed PMID: 23871270; PubMed Central PMCID: PMC3943337.

  12. Francis CS, Mobin SS, Lypka MA, Rommer E, Yen S, Urata MM, Hammoudeh JA. (2013) rhBMP-2 with a Demineralized Bone Matrix Scaffold versus Autologous Iliac Crest Bone Graft for Alveolar Cleft Reconstruction. Plast Reconstr Surg. 2013 May;131(5):1107-15. doi: 10.1097/PRS.0b013e3182865dfb. PubMed PMID: 23385986.

  13. Borzabadi-Farahani A, Yen SL, Francis C, Lara-Sanchez PA, Hammoudeh J. (2013) A rare case of accessory maxilla and bilateral Tessier no. 7 clefts, a 10-year follow-up. J Craniomaxillofac Surg. 2013 Sep;41(6):527-31. doi:10.1016/j.jcms.2012.11.019. Epub 2013 Jan 18. PubMed PMID: 23333494.

  14. Borzabadi-Farahani A, Gross J, Sanchez-Lara P, Yen SL. (2013) An unusual accessory mandible and a sub-mucosal cleft palate-a case report and review of the literature. Cleft Palate Craniofac J. 2013 May;50(3):369-75. doi: 10.1597/11-032. Epub 2012 Oct 31. PubMed PMID: 22404912.

  15. Lypka M, Yen S, Urata M, Hammoudeh J. (2012) Solving convergent vector problems with internal maxillary distractors through the use of a fixed rapid palatal expander. J Oral Maxillofac Surg. 2012 Jul;70(7):e428-30. doi: 10.1016/j.joms.2012.03.013. PubMed PMID: 22698298.

  16. Borzabadi-Farahani A, Groper JN, Tanner AM, Urata MM, Panossian A, Yen SL. (2012) The nance obturator, a new fixed obturator for patients with cleft palate and fistula. J Prosthodont. 2012 Jul;21(5):400-3. doi:10.1111/j.1532-849X.2012.00853.x. Epub 2012 Jun 27. PubMed PMID: 22738139.

  17. Borzabadi-Farahani A, Yen SL, Yamashita DD, Sanchez-Lara PA. (2012) Bilateral maxillary duplication: Case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 May;113(5):e29-32. doi: 10.1016/j.tripleo.2011.06.017. Epub 2011 Sep 16. PubMed PMID: 22676989.

  18. Yen SL. (2011) Protocols for Late Maxillary Protraction in Cleft Lip and Palate Patients at Childrens Hospital Los Angeles. Semin Orthod. 2011 Jun 1;17(2):138-148. PubMed PMID: 21765629; PubMed Central PMCID: PMC3134380.

  19. Wang L, Lee W, Lei DL, Liu YP, Yamashita DD, Yen SL. (2009) Tisssue responses in corticotomy- and osteotomy-assisted tooth movements in rats: histology and immunostaining. Am J Orthod Dentofacial Orthop. 136(6):770.e1-11;discussion 770-1. PubMed PMID: 19962598.

  20. Lypka M, Afshar A, Pham D, Fortman K, Yamashita DD, Yen S. (2009) Implant-supported distraction osteogenesis: a technique to advance the deficient maxilla. J Craniofac Surg. 20(2):525-7. PubMed PMID: 19169158.

  21. Vachiramon A, Urata M, Kyung HM, Yamashita DD, Yen SL. (2009) Clinical applications of orthodontic microimplant anchorage in craniofacial patients. Cleft Palate Craniofac J. 46(2):136-46. PubMed PMID: 19254050.

  22. Lee W, Karapetyan G, Moats R, Yamashita DD, Moon HB, Ferguson DJ, Yen S. (2008) Corticotomy-/Osteotomy-assisted Tooth Movement microCTs Differ. J Dent Res. 87(9):861-7. PubMed PMID: 18719214.

  23. Vachiramon A, Yen SL, Lypka M, Bindignavale V, Hammoudeh J, Reinisch J, Urata MM. (2007) A novel model surgery technique for LeFort III advancement. J Craniofac Surg. 18(5):1230-5. PubMed PMID: 17912119.

  24. Lypka MA, Urata MM, Yen S, Yamashita DD. (2007) Facial nerve paralysis: a complication of distraction osteogenesis of the mandibular ramus in the treatment of temporomandibular joint ankylosis. J Craniofac Surg. 18(4):844-8. PubMed PMID: 17667675.

  25. Wei S, Scadeng M, Yamashita DD, Pollack H, Faridi O, Tran B, Shuler C, Yen S. (2007) Manipulating the mandibular distraction site at different stages of consolidation. J Oral Maxillofac Surg. 65(5):840-6. PubMed PMID: 17448830.

  26. Yen SL, Yamashita DD, Gross J, Meara JG, Yamazaki K, Kim TH, Reinisch J. (2005) Combining orthodontic tooth movement with distraction osteogenesis to close cleft spaces and improve maxillary arch form in cleft lip and palate patients. Am J Orthod Dentofacial Orthop. 127(2):224-32.

  27. Yen SL, Don D, Pollack S, Yamashita DD. (2004) Closed reduction of a symphysis fracture in a 2-month-old infant: treatment considerations. J Trauma. 56(3):706-8.

  28. Bohman P, Yamashita DD, Baek SH, Yen SL. (2004) Stabilization of an edentulous premaxilla for an alveolar bone graft: case report. Cleft Palate Craniofac J. 41(2):214-7.

  29. Yen SL, Yamashita DD, Kim TH, Baek HS, Gross J. (2003) Closure of an unusually large palatal fistula in a cleft patient by bony transport and corticotomy-assisted expansion. J Oral Maxillofac Surg. 61(11):1346-50

  30. Yeung C, Yen SL. (2003) Extrusion of a traumatically injured tooth with a vacuum-formed splint. J Clin Orthod. 37(7):361-3.

  31. Yen SL, Gross J, Yamashita DD, Kim TH, McAndrews J, Shuler C, Reinisch J. (2002) Correcting an Anterior Open-Bite Side Effect during Distraction with Spring Forces. Plast Reconstr Surg, 110(6):1476-84

  32. Yen SL, Shang W, Shuler C, Yamashita DD (2001) Orthodontic spring guidance of bilateral mandibular distraction in rabbits. Am J Orthod Dentofacial Orthop 120: 435-42

  33. Yen SL, Wei S, Li S, Shuler C, Yamashita DD (2001) Bending the Distraction Site during Mandibular Distraction in Rabbits: A Model for Studying Side-effects and Segment Rotations. J Oral Maxillofac Surg 59(7):779-788

  34. Yen S, Gross J, Wang P, Yamashita DD (2001) Closure of a large alveolar cleft by bony transport of a posterior segment using orthodontic archwires attached to bone: report of a case. J Oral Maxillofac Surg 59(6):688-691

  35. Yen S, Shang W, Faber J, et al (1999) Experimental Open Bites by Bilateral Mandibular Distraction in Rabbits. J Oral Maxillofac Surg, 57(8) :97

  36. Yen S (1998) Die Distaktionosteogenese und ihre Anwendung in der Kieferorthopadie. Informationene aus Orthodontie und Kieferorthopadie, 4: 769-780

  37. Yen S, Yamashita DD (1997) New American Heart Association recommendations for prevention of bacterial endocarditis. J Clin Orthod 31: 758-9

  38. Yen SL (1997) Distraction osteogenesis: application to dentofacial orthopedics. Semin Orthod 3: 275-83

  39. MacDougall M, Crall M, Yen S, Slavkin HC (1994) Presence of Dentin Phospoprotein in Molars of a Patient with Dentinogenesis Imperfecta Type II. J. Craniofac Genet Dev Biol 14:25-32

  40. Zeichner-David, M, MacDougall M, Yen S, Hall F, Slavkin HC (1992) Protein kinases in dentinogenesis. Proc Finn Dent Soc, 88(1):295-303

  41. Yen S, Gibbons RJ (1987) Reduction in Bacterial Adsorption to Albumin-Treated Surfaces. Archives of Oral Biology, 32(7):531-533