Jian Xu

CSA 106 - HSC 9062
Phone: (323) 442-4835
Fax: (323) 442-2981
xujian@usc.edu
website:

Jian Xu, Ph.D.

Assistant Professor, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

  • Peking University, Beijing, China
    B.S.
    2000


  • University of Cincinnati/Cincinnati Children’s Hospital, Cincinnati OH
    Ph.D.
    2006
    Pharmacology and Cell Biophysics

  • 2013 - present - Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2011 - 2013 - Research Track Faculty - Dept. Cell and Tissue Biology, University of California, San Francisco, CA
  • 2007 - 2010 - Post-doctoral Fellow - University of California, San Francisco CA
  • 2006 - 2007 - Post-doctoral Fellow - Cincinnati Children’s Hospital, Cincinnati OH
  • 2012 - FASEB Biological Methylation Conference Best Seminar Award
  • 2011-2014 - American Heart Association National Scientist Development Grant
  • 2011 - Tokyo Global Center of Excellence Retreat Poster Award
  • 2009-2010 - Foundation Independent Postdoctoral Research Fellowship
  • 2007-2009 - American Heart Association Postdoctoral Fellowship
  • 2003 - University of Cincinnati Graduate Student Poster Forum, Poster Award
  • 2001-2003 - American Heart Association Pre-doctoral Fellowship
  • 2000 - Peking University Health Science Center Undergraduate Dissertation Award
  • 1995-2000 - Peking University Outstanding Student Scholarship

Arginine methylation of inhibitory Smads: role in TGF-beta/BMP signaling and differentiation - Grant #11SDG5220002

  • Principal Investigator: Jian Xu, Ph.D.
  • Sponsor: American Heart Association
  • Period: 01/01/2011-12/31/2015
  • Goal: To provide novel insights in the regulation of Smad signaling by methylation and its physiological significance.

Arginine methylation of inhibitory Smads regulates TGF-beta/BMP signaling and endothelial/epicardial transdifferentiation - Grant #16BGIA26540000

  • Principal Investigator: Jian Xu, Ph.D.
  • Sponsor: American Heart Association
  • Period: 01/01/2016-12/31/2017
  • Goal: To investigate molecular regulatory mechanisms during epicardial and endothelial-to-mesenchymal transdifferentiation.

Fibroblast fate transition in cardiac injury repair - Grant #

  • Principal Investigator: Jian Xu, Ph.D.
  • Sponsor: the Audrey E. Streedain Trust
  • Period: 01/01/2016-06/30/2017
  • Goal: To identify the role of PRMT1-p53 axis in cardiac fibroblast fate transition in the injured heart.

Methylation signaling in periodontal health and disease - Grant #5 R01 DE026468

  • Principal Investigator: Jian Xu, Ph.D.
  • Sponsor: NIDCR/NIH
  • Period: 07/01/2017-06/30/2022
  • Goal: To investigate the roles of Smad6 methylation in the signaling crosstalk between TGFbeta and TLR-NFkB pathways and periodontal inflammatory responses.
  1. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. (2017) BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jul 15;144(14):2560-2569. doi: 10.1242/dev.150136. Epub 2017 Jun 2. PubMed PMID: 28576771.

  2. Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B. (2017) Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147. doi: 10.1096/fj.201600631R. PubMed PMID: 27694478; PubMed Central PMCID: PMC5161519.

  3. Budi EH, Xu J, Derynck R. (2016) Regulation of TGF-beat Receptors. Methods Mol Biol. 2016;1344:1-33. doi: 10.1007/978-1-4939-2966-5_1. PubMed PMID: 26520115.

  4. Ma M, Li P, Shen H, Estrada KD, Xu J, Kumar SR, Sucov HM. (2016) Dysregulated endocardial TGFbeta signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016 Jan 1;409(1):272-6. doi:10.1016/j.ydbio.2015.09.021. Epub 2015 Oct 29. PubMed PMID: 26522286; PubMed Central PMCID: PMC4742370.

  5. Gou Y, Zhang T, Xu J. (2015) Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation. Curr Top Dev Biol. 2015;115:377-410. doi: 10.1016/bs.ctdb.2015.07.009. Epub 2015 Oct 6. PubMed PMID: 26589933.

  6. Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar SR, Sucov HM. (2015) Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2070-5. doi: 10.1073/pnas.1417232112. Epub 2015 Feb 2. PubMed PMID: 25646471; PubMed Central PMCID: PMC4343131.

  7. Xu J, Derynck R. (2014) Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014 Apr 15;13(8):1209-10. doi: 10.4161/cc.28380. Epub 2014 Mar 5. PubMed PMID: 24621505; PubMed Central PMCID: PMC4049950.

  8. Lamouille S, Xu J, Derynck R. (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96. doi: 10.1038/nrm3758. Review. PubMed PMID: 24556840; PubMed Central PMCID: PMC4240281.

  9. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. (2013) Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11;51(1):5-19. doi:10.1016/j.molcel.2013.05.004. PubMed PMID: 23747011; PubMed Central PMCID:PMC3951972.

  10. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. (2010) CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug;16(8):872-9. doi: 10.1038/nm.2181. Epub 2010 Jul 18. PubMed PMID: 20639889; PubMed Central PMCID: PMC2917617.

  11. Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD. (2010) Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010 Jan 26;121(3):419-25. doi:10.1161/CIRCULATIONAHA.109.882068. Epub 2010 Jan 11. PubMed PMID: 20065166;PubMed Central PMCID: PMC2823256.

  12. Liu C, Xu P, Lamouille S, Xu J, Derynck R. (2009) TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10;35(1):26-36. doi: 10.1016/j.molcel.2009.06.018. PubMed PMID: 19595713; PubMed Central PMCID: PMC2740991.

  13. Xu J, Lamouille S, Derynck R. (2009) TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb;19(2):156-72. doi: 10.1038/cr.2009.5. Review. PubMed PMID: 19153598; PubMed Central PMCID: PMC4720263.

  14. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Molkentin JD. (2007) Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. 2007 Nov;117(11):3198-210. Erratum in: J Clin Invest. 2008 Jan;118(1):387. PubMed PMID: 17975667; PubMed Central PMCID: PMC2045611.

  15. Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW 2nd, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. (2007) Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21. Epub 2007 Jun 14. PubMed PMID: 17569887; PubMed Central PMCID: PMC2680305.

  16. Oka T, Xu J, Molkentin JD. (2007) Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007 Feb;18(1):117-31. Epub 2006 Nov 24. Review. PubMed PMID: 17161634; PubMed Central PMCID: PMC1855184.

  17. Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD. (2006) Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem. 2006 Apr 7;281(14):9152-62. Epub 2006 Feb 9. PubMed PMID: 16469744.

  18. Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, Wollert KC. (2006) The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res. 2006 Feb 17;98(3):351-60. Epub 2006 Jan 5. PubMed PMID: 16397141.

  19. Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD. (2006) GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res. 2006 Feb 17;98(3):342-50. Epub 2006 Jan 5. PubMed PMID: 16397142.

  20. Dai YS, Xu J, Molkentin JD. (2005) The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005 Nov;25(22):9936-48. PubMed PMID: 16260608; PubMed Central PMCID: PMC1280278.

  21. Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, Molkentin JD, Agellon LB, Michalak M. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol. 2005 Jul 4;170(1):37-47. PubMed PMID: 15998798; PubMed Central PMCID: PMC2171392.

  22. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. (2004) Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004 Jan 9;94(1):110-8. Epub 2003 Dec 1. PubMed PMID: 14656927.