Baruch Frenkel

CSC 262 - HSC 9075
Phone: (323) 442-1322
Fax: (323) 442-2764

Baruch Frenkel, D.M.D., Ph.D.

J. Harold and Edna L. LaBriola Professor, Orthopaedic Surgery and Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA

Professor, Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of USC

  • Hebrew Univ. Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Dental Sciences

  • Hebrew Univ. Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Dental Medicine

  • Hebrew Univ. Hadassah Faculty of Dental Medicine, Jerusalem, Israel

  • 2016 - present - Professor - Center for Craniofacial Molecular Biology, Ostrow School of Dentistry of USC
  • 2011 - present - J. Harold and Edna L. LaBriola Professor - Orthopaedic Surgery and Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • 2003 - 2011 - Associate Professor - Orthopaedic Surgery and Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • 1997 - 2003 - Assistant Professor - Orthopaedic Surgery and Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • 1993 - 1997 - Instructor of Cell Biology - University of Massachusetts Medical Center, Worcester, MA
  • 1991 - 1993 - Postdoc.- Cell Biology - University of Massachusetts Medical Center, Worcester, MA
  • 2016 - Ad hoc Reviewer, SBSR
  • 2016 - Ad hoc Reviewer, Israel Science Foundation
  • 2015 - Ad hoc Reviewer, R24 study section, NIDDK
  • 2013 - Ad hoc Reviewer, Breast Cancer Campaign, UK
  • 2012-2014 - Ad hoc Reviewer, Research Grant Council of Hong Kong
  • 2012 - Ad hoc Reviewer, Welcome Trust Training Program, UK
  • 2012 - Ad hoc Reviewer, National Fund for Scientific & Technological Development, Chile
  • 2011-2013 - Editorial Board, Journal of Bone and Mineral Research
  • 2007-2009 - Ad hoc Grant Review for the Australian National Health and Medical Research Council
  • 2006-present - Ad hoc Reviewer, US-Israel Bi-national Science Foundation
  • 2006 - James R. Klinenberg Science Award, Arthritis Foundation
  • 2004-present - J. Harold and Edna L. LaBriola Chair in Genetic Orthopaedic Research
  • 2003-present - Editorial Board, Journal of Cellular Biochemistry
  • 2002-2003 - James R. Klinenberg Science Award, Arthritis Foundation
  • 2001-present - Ad hoc reviewer, NIH (regular study sections, special emphasis panels)
  • 2000-2003 - Member, NIAMS Study Section, RO3 New Investigator Awards
  • 1999-2002 - Ad hoc Reviewer, VA Endocrinology Study Section
  • 1999 - Jeanette Wilkins Award for the Best Basic Science Paper in the MSIS meeting
  • 1992 - Merck Sharp and Dohme Young Investigator Award
  • 1991 - Merck Sharp and Dohme Travel Award
  • 1990 - Lady Davis Fellow
  • 1987 - Hermel Excellence Award for D.M.D. Thesis
  • 1986-1989 - Foulkes Foundation Fellow
  • 1983 - Excellence Award from the Rector of the Hebrew University of Jerusalem

Completed Grants

Runx Proteins and Sex Steroid Signaling in Bone - Grant #2 R56 DK 071122

  • Principal Investigator: Baruch Frenkel, DMD, PhD
  • Sponsor: National Institutes of Health
  • Period: 04/01/2005-06/30/2010
  • Goal: The goal of this project is to ultimately lead to the development of improved drugs to treat postmenopausal osteoporosis.

Sex Steroids and Runx Signaling in Bone - Grant #5 R01 DK071122

  • Principal Investigator: Baruch Frenkel, DMD, PhD
  • Sponsor: National Institutes of Health
  • Period: 07/01/2010-06/30/2015
  • Goal: The revised goal of this project is to investigate interactions between RUNX2 and sex steroid hormones in bone, prostate cancer and breast cancer.

Krox20 and Bone Mass - Grant #5 R01 AR 047052

  • Principal Investigator: Baruch Frenkel, DMD, PhD
  • Sponsor: National Institutes of Health
  • Period: 09/01/2006-07/31/2011
  • Goal: The goals of this project are to manipulate Krox20 (Egr2) gene expression and investigate the effects on osteoblast growth and differentiation in vitro and on bone mass in vivo.
  1. Sabag E, Halperin E, Liron T, Hiram-Bab S, Frenkel B, Gabet Y. (2019) Hormone-Independent Sexual Dimorphism in the Regulation of Bone Resorption by Krox20. J Bone Miner Res. 2019 Aug 9. doi: 10.1002/jbmr.3847. [Epub ahead of print] PubMed PMID: 31398266.

  2. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. (2018) CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 Dec 15;143(12):3169-3180. doi:10.1002/ijc.31734. Epub 2018 Oct 16. PubMed PMID: 30325015; PubMed Central PMCID:PMC6263834.

  3. Amzaleg Y, Ji J, Kittivanichkul D, E Törnqvist A, Windahl S, Sabag E, Khalid AB, Sternberg H, West M, Katzenellenbogen JA, Krum SA, Chimge NO, Schones DE, Gabet Y, Ohlsson C, Frenkel B. (2018) Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells. J Steroid Biochem Mol Biol. 2018 Oct;183:10-17. doi: 10.1016/j.jsbmb.2018.05.002. Epub 2018 May 8. PubMed PMID: 29751107; PubMed Central PMCID: PMC6128776.

  4. Martin A, Yu J, Xiong J, Khalid AB, Katzenellenbogen B, Kim SH, Katzenellenbogen JA, Malaivijitnond S, Gabet Y, Krum SA, Frenkel B. (2017) Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms. J Cell Physiol. 2017 Dec;232(12):3798-3807. doi:10.1002/jcp.25862. Epub 2017 May 11. PubMed PMID: 28213978; PubMed Central PMCID: PMC5562539.

  5. Chimge NO, Ahmed-Alnassar S, Frenkel B. (2017) Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer. Cell Cycle. 2017 Feb 16;16(4):312-318. doi: 10.1080/15384101.2016.1237325. Epub 2017 Jan 5. PubMed PMID: 28055379; PubMed Central PMCID: PMC5324758.

  6. Morimoto E, Li M, Khalid AB, Krum SA, Chimge NO, Frenkel B. (2017) Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation. J Cell Physiol. 2017 Jan;232(1):145-53. doi: 10.1002/jcp.25399. Epub 2016 Apr 26. PubMed PMID: 27061521; PubMed Central PMCID: PMC5540653.

  7. Vuong W, Tew BY, Little GH, Frenkel B, Jones JO. (2016) High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov;359(2):256-261. Epub 2016 Aug 23. PubMed PMID: 27554677.

  8. Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. (2016) Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 May 19;62(4):507-19. doi: 10.1016/j.molcel.2016.04.014. PubMed PMID: 27203177; PubMed Central PMCID: PMC4875571.

  9. Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. (2016) RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer. Nat Commun. 2016 Feb 26;7:10751. doi: 10.1038/ncomms10751. PubMed PMID: 26916619; PubMed Central PMCID: PMC4773428.

  10. Frenkel B, White W, Tuckermann J. (2015) Glucocorticoid-Induced Osteoporosis. Adv Exp Med Biol. 2015;872:179-215. doi: 10.1007/978-1-4939-2895-8_8. Review. PubMed PMID: 26215995.

  11. HaDuong JH, Blavier L, Baniwal SK, Frenkel B, Malvar J, Punj V, Sposto R, DeClerck YA. (2015) Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer. 2015 Aug 15;137(4):797-809. doi: 10.1002/ijc.29465. Epub 2015 Feb 21. PubMed PMID: 25648303.

  12. Martin A, Xiong J, Koromila T, Ji JS, Chang S, Song YS, Miller JL, Han CY, Kostenuik P, Krum SA, Chimge NO, Gabet Y, Frenkel B. (2015) Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone. 2015 Jun;75:96-104. doi: 10.1016/j.bone.2015.02.007. Epub 2015 Feb 17. PubMed PMID: 25701138; PubMed Central PMCID: PMC4387095.

  13. Yu JL, Adisetiyo H, Little GH, Vangsness CT Jr, Jiang J, Sternberg H, West MD, Frenkel B. (2015) Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line. J Cell Physiol. 2015 Feb;230(2):237-41. doi: 10.1002/jcp.24773. PubMed PMID: 25160731.

  14. Adisetiyo H, Liang M, Liao CP, Jeong JH, Cohen MB, Roy-Burman P, Frenkel B. (2014) Dependence of castration-resistant prostate cancer (CRPC) stem cells on CRPC-associated fibroblasts. J Cell Physiol. 2014 Sep;229(9):1170-6. doi: 10.1002/jcp.24546. PubMed PMID: 24752784.

  15. Little GH, Baniwal SK, Adisetiyo H, Groshen S, Chimge NO, Kim SY, Khalid O, Hawes D, Jones JO, Pinski J, Schones DE, Frenkel B. (2014) Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness. Cancer Res. 2014 May 15;74(10):2857-68. doi: 10.1158/0008-5472.CAN-13-2003. Epub 2014 Mar 19. PubMed PMID: 24648349; PubMed Central PMCID: PMC4051204.

  16. Soung do Y, Kalinowski J, Baniwal SK, Jacome-Galarza CE, Frenkel B, Lorenzo J, Drissi H. (2014) Runx1-mediated regulation of osteoclast differentiation and function. Mol Endocrinol. 2014 Apr;28(4):546-53. doi: 10.1210/me.2013-1305. Epub 2014 Feb 25. PubMed PMID: 24606124; PubMed Central PMCID: PMC3968404.

  17. Koromila T, Baniwal SK, Song YS, Martin A, Xiong J, Frenkel B. (2014) Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells. J Cell Biochem. 2014 Jan;115(1):27-33. doi: 10.1002/jcb.24646. PubMed PMID: 23943595.

  18. Pham LK, Liang M, Adisetiyo HA, Liao CP, Cohen MB, Tahara SM, Frenkel B, Kasahara N, Roy-Burman P. (2013) Contextual effect of repression of bone morphogenetic protein activity in prostate cancer. Endocr Relat Cancer. 2013 Nov 4;20(6):861-74. doi: 10.1530/ERC-13-0100. Print 2013 Dec. PubMed PMID: 24042462; PubMed Central PMCID: PMC3885249.

  19. Baniwal SK, Chimge NO, Jordan VC, Tripathy D, Frenkel B. (2013) Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner. PLoS One. 2013 Jun 3;8(6):e62361. doi:10.1371/journal.pone.0062361. Print 2014. PubMed PMID: 23755096; PubMed Central PMCID: PMC3670933.

  20. Windahl SH, Saxon L, Börjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjögren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C. (2013) Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res. 2013 Feb;28(2):291-301. doi: 10.1002/jbmr.1754. PubMed PMID: 22972752; PubMed Central PMCID: PMC3575695.

  21. Chimge NO, Frenkel B. (2013) The RUNX family in breast cancer: relationships with estrogen signaling. Oncogene. 2013 Apr 25;32(17):2121-30. doi: 10.1038/onc.2012.328. Epub 2012 Oct 8. Review. PubMed PMID: 23045283.

  22. Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR. (2012) Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012 Jul;113(7):2406-14. doi: 10.1002/jcb.24114. PubMed PMID: 22389001; PubMed Central PMCID: PMC3350606.

  23. Baniwal SK, Little GH, Chimge NO, Frenkel B. (2012) Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation. J Cell Physiol. 2012 May;227(5):2276-82. doi:10.1002/jcp.22966. PubMed PMID: 21809344; PubMed Central PMCID: PMC3376385.

  24. Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L. (2012) Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs. Lab Invest. 2012 Jun;92(6):802-11. doi: 10.1038/labinvest.2012.58. Epub 2012 Apr 9. PubMed PMID: 22488153; PubMed Central PMCID: PMC4530993.

  25. Ting MC, Liao CP, Yan C, Jia L, Groshen S, Frenkel B, Roy-Burman P, Coetzee GA, Maxson R. (2012) An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice. Dis Model Mech. 2012 May;5(3):366-74. doi:10.1242/dmm.008458. Epub 2012 Jan 25. PubMed PMID: 22279083; PubMed Central PMCID: PMC3339830.

  26. Little GH, Noushmehr H, Baniwal SK, Berman BP, Coetzee GA, Frenkel B. (2012) Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012 Apr;40(8):3538-47. doi:10.1093/nar/gkr1219. Epub 2011 Dec 19. PubMed PMID: 22187159; PubMed Central PMCID: PMC3333873.

  27. Chimge NO, Baniwal SK, Luo J, Coetzee S, Khalid O, Berman BP, Tripathy D, Ellis MJ, Frenkel B. (2012) Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness. Clin Cancer Res. 2012 Feb 1;18(3):901-11. doi: 10.1158/1078-0432.CCR-11-1530. Epub 2011 Dec 6. PubMed PMID: 22147940; PubMed Central PMCID: PMC3277803.

  28. Baniwal SK, Shah PK, Shi Y, Haduong JH, Declerck YA, Gabet Y, Frenkel B. (2012) Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells. Osteoporos Int. 2012 Apr;23(4):1399-413. doi:10.1007/s00198-011-1728-5. Epub 2011 Sep 1. PubMed PMID: 21881969.

  29. Chimge NO, Baniwal SK, Little GH, Chen YB, Kahn M, Tripathy D, Borok Z, Frenkel B. (2011) Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011;13(6):R127. doi: 10.1186/bcr3073. Epub 2011 Dec 9. PubMed PMID: 22151997; PubMed Central PMCID:PMC3326569.

  30. Andreu-Vieyra C, Lai J, Berman BP, Frenkel B, Jia L, Jones PA, Coetzee GA. (2011) Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. Mol Cell Biol. 2011 Dec;31(23):4648-62. doi: 10.1128/MCB.05934-11. Epub 2011 Oct 3. PubMed PMID: 21969603; PubMed Central PMCID: PMC3232925.

  31. Gabet Y, Noh T, Lee C, Frenkel B. (2011) Developmentally regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin A transcription in primary osteoblast cultures. J Cell Physiol. 2011 Apr;226(4):991-8. doi:10.1002/jcp.22412. PubMed PMID: 20857405.

  32. Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C. (2011) Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93. doi: 10.1073/pnas.1100454108. Epub 2011 Mar 28. PubMed PMID: 21444817; PubMed Central PMCID: PMC3076831.

  33. Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. (2011) CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts. J Bone Miner Res. 2011 Feb;26(2):308-16. doi: 10.1002/jbmr.228. PubMed PMID: 20803555; PubMed Central PMCID: PMC3179350.

  34. Baniwal SK, Khalid O, Gabet Y, Shah RR, Purcell DJ, Mav D, Kohn-Gabet AE, Shi Y, Coetzee GA, Frenkel B. (2010) Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. Mol Cancer. 2010 Sep 23;9:258. doi:10.1186/1476-4598-9-258. PubMed PMID: 20863401; PubMed Central PMCID: PMC2955618.

  35. Gabet Y, Baniwal SK, Leclerc N, Shi Y, Kohn-Gabet AE, Cogan J, Dixon A, Bachar M, Guo L, Turman JE Jr, Frenkel B. (2010) Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass. Blood. 2010 Nov 11;116(19):3964-71. doi: 10.1182/blood-2010-01-263830. Epub 2010 Aug 17. PubMed PMID: 20716776; PubMed Central PMCID: PMC2981544.

  36. Frenkel B, Hong A, Baniwal SK, Coetzee GA, Ohlsson C, Khalid O, Gabet Y. (2010) Regulation of adult bone turnover by sex steroids. J Cell Physiol. 2010 Aug;224(2):305-10. doi: 10.1002/jcp.22159. Review. PubMed PMID: 20432458.

  37. Berman BP, Frenkel B, Coetzee GA, Jia L. (2010) Androgen receptor responsive enhancers are flanked by consistently-positioned H3-acetylated nucleosomes. Cell Cycle. 2010 Jun 1;9(11):2249-50. Epub 2010 Jun 1. PubMed PMID: 20495358; PubMed Central PMCID: PMC4373526.

  38. Coetzee GA, Jia L, Frenkel B, Henderson BE, Tanay A, Haiman CA, Freedman ML. (2010) A systematic approach to understand the functional consequences of non-protein coding risk regions. Cell Cycle. 2010 Jan 15;9(2):256-9. Epub 2010 Jan 23. PubMed PMID: 20023379; PubMed Central PMCID: PMC3319348.

  39. Jia L, Landan G, Pomerantz M, Jaschek R, Herman P, Reich D, Yan C, Khalid O, Kantoff P, Oh W, Manak JR, Berman BP, Henderson BE, Frenkel B, Haiman CA, Freedman M, Tanay A, Coetzee GA. (2009) Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet. 2009 Aug;5(8):e1000597. doi: 10.1371/journal.pgen.1000597. Epub 2009 Aug 14. PubMed PMID: 19680443; PubMed Central PMCID: PMC2717370.

  40. Warotayanont R, Frenkel B, Snead ML, Zhou Y. (2009) Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway. Biochem Biophys Res Commun. 387(3):558-63. PubMed PMID: 19615979; PubMed Central PMCID: PMC2758297.

  41. Pomerantz MM, Ahmadiyeh N, Jia L, Herman P, Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Lenz HJ, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA, Freedman ML. (2009) The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug;41(8):882-4. doi: 10.1038/ng.403. Epub 2009 Jun 28. PubMed PMID: 19561607; PubMed Central PMCID: PMC2763485.

  42. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixson A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Muller R, Chai Y, Smith E, Bab I, Frenkel B. (2009) Lef1 haploinsufficiency mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS ONE 4(5):e5438. PubMed PMID: 19412553; PubMed Central PMCID: PMC2673053.

  43. Berman BP, Frenkel B, Coetzee GA. (2009) Location, location, (ChIP-)location! Mapping chromatin landscapes one immunoprecipitation at a time. J Cell Biochem. 2009 May 1;107(1):1-5. doi: 10.1002/jcb.22133. PubMed PMID: 19308935; PubMed Central PMCID: PMC2748114.

  44. Baniwal SK, Khalid O, Sir D, Buchanan G, Coetzee GA, Frenkel B. (2009) Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol. 2009 Aug;23(8):1203-14. doi: 10.1210/me.2008-0470. Epub 2009 Apr 23. PubMed PMID: 19389811; PubMed Central PMCID: PMC2718746.

  45. Jariwala U, Cogan JP, Jia L, Frenkel B, Coetzee GA. (2009) Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. Prostate. 2009 Mar 1;69(4):392-400. doi: 10.1002/pros.20893. PubMed PMID: 19058140; PubMed Central PMCID: PMC2743387.

  46. Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, Walters A, Chen T, Buchanan G, Frenkel B, Coetzee GA. (2008) Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One. 2008;3(11):e3645. doi: 10.1371/journal.pone.0003645. Epub 2008 Nov 10. PubMed PMID: 18997859; PubMed Central PMCID: PMC2577007.

  47. Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B. (2008) Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation. J Cell Biochem. 2008 Nov 1;105(4):965-70. doi:10.1002/jcb.21900. PubMed PMID: 18821584; PubMed Central PMCID: PMC2591066.

  48. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. (2008) GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov;295(5):C1141-50. doi: 10.1152/ajpcell.00120.2008. Epub 2008 Sep 3. PubMed PMID: 18768929; PubMed Central PMCID: PMC2584994.

  49. Khalid O, Baniwal SK, Purcell DJ, Leclerc N, Gabet Y, Stallcup MR, Coetzee GA, Frenkel B. (2008) Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. Endocrinology. 2008 Dec;149(12):5984-95. doi: 10.1210/en.2008-0680. Epub 2008 Aug 28. PubMed PMID:18755791; PubMed Central PMCID: PMC2613062.

  50. Luppen CA, Chandler RL, Noh T, Mortlock DP, Frenkel B. (2008) BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization. Growth Factors. 2008 Aug;26(4):226-37. doi: 10.1080/08977190802277880. PubMed PMID: 19021035; PubMed Central PMCID: PMC3760374.

  51. Leclerc N, Noh T, Cogan J, Samarawickrama DB, Smith E, Frenkel B. (2008) Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures. J Cell Biochem. 2008 Apr 15;103(6):1938-51. PubMed PMID:17973254.

  52. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. (2008) Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun;38(6):750-8. doi: 10.1165/rcmb.2007-0350OC. Epub 2008 Jan 31. PubMed PMID: 18239190; PubMed Central PMCID: PMC2396252.

  53. Yang S, Pham LK, Liao CP, Frenkel B, Reddi AH, Roy-Burman P. (2008) A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer. Cancer Res. 2008 Jan 1;68(1):198-205. doi: 10.1158/0008-5472.CAN-07-5074. PubMed PMID: 18172312.

  54. Barski A, Pregizer S, Frenkel B. (2008) Identification of transcription factor target genes by ChIP display. Methods Mol Biol. 2008;455:177-90. doi:10.1007/978-1-59745-104-8_14. PubMed PMID: 18463820.

  55. Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B. (2007) Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem. 2007 Dec 15;102(6):1458-71. PubMed PMID: 17486635.

  56. Prescott J, Jariwala U, Jia L, Cogan JP, Barski A, Pregizer S, Shen HC, Arasheben A, Neilson JJ, Frenkel B, Coetzee GA. (2007) Androgen receptor-mediated repression of novel target genes. Prostate. 2007 Sep 15;67(13):1371-83. PubMed PMID: 17624924.

  57. Jariwala U, Prescott J, Jia L, Barski A, Pregizer S, Cogan JP, Arasheben A, Tilley WD, Scher HI, Gerald WL, Buchanan G, Coetzee GA, Frenkel B. (2007) Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer. 2007 Jun 6;6:39. PubMed PMID: 17553165; PubMed Central PMCID: PMC1904239.

  58. Zhu W, Boachie-Adjei O, Rawlins BA, Frenkel B, Boskey AL, Ivashkiv LB, Blobel CP. (2007) A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. J Biol Chem. 2007 Jun 29;282(26):18676-85. Epub 2007 Apr 17. PubMed PMID: 17439946.

  59. Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I. (2006) Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):696-701. Epub 2006 Jan 9. PubMed PMID: 16407142; PubMed Central PMCID: PMC1334629.

  60. Miguel SM, Namdar-Attar M, Noh T, Frenkel B, Bab I. (2005) ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells. J Biol Chem. 2005 Nov 11;280(45):37495-502. Epub 2005 Sep 2. PubMed PMID: 16150701.

  61. Yang S, Zhong C, Frenkel B, Reddi AH, Roy-Burman P. (2005) Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res. 2005 Jul 1;65(13):5769-77. PubMed PMID: 15994952.

  62. Leclerc N, Noh T, Khokhar A, Smith E, Frenkel B. (2005) Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Arthritis Rheum. 2005 Mar;52(3):929-39. PubMed PMID: 15751078.

  63. Smith E, Meyerrose TE, Kohler T, Namdar-Attar M, Bab N, Lahat O, Noh T, Li J, Karaman MW, Hacia JG, Chen TT, Nolta JA, Müller R, Bab I, Frenkel B. (2005) Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucleic Acids Res. 2005 Mar 1;33(4):1298-308. Print 2005. PubMed PMID: 15741183; PubMed Central PMCID: PMC552952.

  64. Smith E, Frenkel B. (2005) Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner. J Biol Chem. 2005 Jan 21;280(3):2388-94. Epub 2004 Nov 10. PubMed PMID: 15537647.

  65. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia JG, Smith E, Frenkel B. (2004) Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol. 2004 Aug;33(1):175-93. PubMed PMID: 15291752.

  66. Barski A, Frenkel B. (2004) ChIP Display: novel method for identification of genomic targets of transcription factors. Nucleic Acids Res. 2004 Jul 13;32(12):e104. PubMed PMID: 15252151; PubMed Central PMCID: PMC484196.

  67. Luppen CA, Leclerc N, Noh T, Barski A, Khokhar A, Boskey AL, Smith E, Frenkel B. (2003) Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2. J Biol Chem. 2003 Nov 7;278(45):44995-5003. Epub 2003 Aug 20. PubMed PMID: 12933820.

  68. Luppen CA, Smith E, Spevak L, Boskey AL, Frenkel B. (2003) Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures. J Bone Miner Res. 2003 Jul;18(7):1186-97. PubMed PMID: 12854828.

  69. Zalavras C, Shah S, Birnbaum MJ, Frenkel B. (2003) Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. Crit Rev Eukaryot Gene Expr. 2003;13(2-4):221-35. Review. PubMed PMID: 14696969.

  70. Smith E, Coetzee GA, Frenkel B. (2002) Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta. J Biol Chem. 2002 May 17;277(20):18191-7. Epub 2002 Feb 27. PubMed PMID: 11877389.

  71. Holtom PD, Pavkovic SA, Bravos PD, Patzakis MJ, Shepherd LE, Frenkel B. (2000) Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro. J Orthop Res. 2000 Sep;18(5):721-7. PubMed PMID: 11117292.

  72. Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B. (2000) Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem. 2000 Jun 30;275(26):19992-20001. PubMed PMID: 10867026.

  73. Hou Z, Nguyen Q, Frenkel B, Nilsson SK, Milne M, van Wijnen AJ, Stein JL, Quesenberry P, Lian JB, Stein GS. (1999) Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7294-9. PubMed PMID: 10377408; PubMed Central PMCID: PMC22079.

  74. Bab I, Smith E, Gavish H, Attar-Namdar M, Chorev M, Chen YC, Muhlrad A, Birnbaum MJ, Stein G, Frenkel B. (1999) Biosynthesis of osteogenic growth peptide via alternative translational initiation at AUG85 of histone H4 mRNA. J Biol Chem. 1999 May 14;274(20):14474-81. PubMed PMID: 10318873.

  75. Nilsson SK, Dooner MS, Weier HU, Frenkel B, Lian JB, Stein GS, Quesenberry PJ. (1999) Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med. 1999 Feb 15;189(4):729-34. PubMed PMID: 9989988; PubMed Central PMCID: PMC2192923.

  76. Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein GS, Stein JL. (1999) Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry. 1999 Jan 26;38(4):1338-45. PubMed PMID: 9930996.

  77. Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL. (1999) AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology. 1999 Jan;140(1):63-70. PubMed PMID: 9886808.

  78. Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ, Lian JB. (1997) Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Mol Endocrinol. 1997 Oct;11(11):1681-94. PubMed PMID: 9328350.

  79. Smith E, Frenkel B, MacLachlan TK, Giordano A, Stein JL, Lian JB, Stein GS. (1997) Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: inhibition by proliferating osteoblasts and osteosarcoma cells. J Cell Biochem. 1997 Aug 1;66(2):141-52. PubMed PMID: 9213216.

  80. Lian JB, Shalhoub V, Aslam F, Frenkel B, Green J, Hamrah M, Stein GS, Stein JL. (1997) Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression. Endocrinology. 1997 May;138(5):2117-27. PubMed PMID: 9112412.

  81. Frenkel B, Capparelli C, Van Auken M, Baran D, Bryan J, Stein JL, Stein GS, Lian JB. (1997) Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology. 1997 May;138(5):2109-16. PubMed PMID: 9112411.

  82. Guo B, Aslam F, van Wijnen AJ, Roberts SG, Frenkel B, Green MR, DeLuca H, Lian JB, Stein GS, Stein JL. (1997) YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):121-6. PubMed PMID: 8990171; PubMed Central PMCID: PMC19252.

  83. Montecino M, Frenkel B, Lian J, Stein J, Stein G. (1996) Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells. J Cell Biochem. 1996 Nov 1;63(2):221-8. PubMed PMID: 8913873.

  84. Banerjee C, Stein JL, Van Wijnen AJ, Frenkel B, Lian JB, Stein GS. (1996) Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology. 1996 May;137(5):1991-2000. PubMed PMID: 8612540.

  85. Frenkel B, Montecino M, Green J, Aslam F, Desai R, Banerjee C, Stein JL, Lian JB, Stein GS. (1996) Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain. Endocrinology. 1996 Mar;137(3):1080-88. PubMed PMID: 8603577.

  86. Smith E, Frenkel B, Schlegel R, Giordano A, Lian JB, Stein JL, Stein GS. (1995) Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E. Cancer Res. 1995 Nov 1;55(21):5019-24. PubMed PMID: 7585545.

  87. Birnbaum MJ, Wright KL, van Wijnen AJ, Ramsey-Ewing AL, Bourke MT, Last TJ, Aziz F, Frenkel B, Rao BR, Aronin N, et al. (1995) Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene. Biochemistry. 1995 Jun 13;34(23):7648-58. PubMed PMID: 7779811.

  88. Frenkel B, Montecino M, Stein JL, Lian JB, Stein GS. (1994) A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: promoter and cell type requirements. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10923-7. PubMed PMID: 7971985; PubMed Central PMCID: PMC45138.

  89. Frenkel B, Bishara-Shieban J, Bar-Tana J. (1994) The effect of beta,beta`-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III. Biochem J. 1994 Mar 1;298 ( Pt 2):409-14. PubMed PMID: 8135749; PubMed Central PMCID: PMC1137955.

  90. Frenkel B, Mijnes J, Aronow MA, Zambetti G, Banerjee C, Stein JL, Lian JB, Stein GS. (1993) Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene. Biochemistry. 1993 Dec 14;32(49):13636-43. PubMed PMID: 7504955.

  91. Frenkel B, Mayorek N, Hertz R, Bar-Tana J. (1988) The hypochylomicronemic effect of beta,beta`-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III. J Biol Chem. 1988 Jun 15;263(17):8491-7. PubMed PMID: 3372539.

  92. Bar-Tana J, Rose-Kahn G, Frenkel B, Shafer Z, Fainaru M. (1988) Hypolipidemic effect of beta, beta`-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats. J Lipid Res. 1988 Apr;29(4):431-41. PubMed PMID: 3392461.