Yan Zhou

CSA A-207 - HSC 9062
Phone: (323) 442-2573
Fax: (323) 442-2981
yzhou@usc.edu
website:

Yan Zhou, Ph.D.

Research Assistant Professor, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

  • Fudan University, Shanghai, China
    B.Sc.
    1990
    Genetics and Genetic Engineering

  • Indiana University, Bloomington, IN

    1995-97
    Molecular, Cellular and Developmental Biology

  • University of Southern California, Los Angeles, CA
    Ph.D.
    2000
    Craniofacial Biology

  • 2003 - present - Research Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2001 - 2002 - Postdoctoral Bioinformatics Scientist - Genentech Inc., San Francisco, CA
  • 2000 - 2000 - Postdoctoral Research Associate, Center of Craniofacial Molecular Biology - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1997 - 2000 - Graduate Research Assistant, Center of Craniofacial Molecular Biology - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1996 - 1997 - Graduate Research Assistant - Indiana University, Bloomington, IN
  • 1990 - 1995 - Research Assistant - Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, China
  • 2002 - Recognition Award, Genentech Inc.
  • 2000 - Academic Achievement Award, University of Southern California
  • 1995 - Predoctoral Fellowship, Department of Biology, Indiana University, Bloomington, IN
  • 1986 - Fudan University Scholarship, Department of genetics and Genetic Engineering, Fudan University, Shanghai, China

Embryonic Stem Cells and Neural Crest Plasticity

  • Principal Investigator: Yan Zhou , Ph.D.
  • Sponsor: National Institute of Dental and Craniofacial Research, NIH
  • Period: 06/05/07-05/31/09
  • Goal: The objective of this project is to regenerate tooth organ using dental mesenchyme derived from mouse embryonic stem cells.

Human Embryonic Stem Cells and Neural Crest Osteogenesis

  • Principal Investigator: Yan Zhou, Ph.D.
  • Sponsor: James H. Zumberge Faculty Research & Innovation Fund
  • Period: 07/01/07-06/30/09
  • Goal: The goal of this project is to investigate signaling effect of amelogenin on directing osteogenic differentiation of human embryonic stem cells.
  1. Newcomb CJ, Sur S, Lee SS, Yu JM, Zhou Y, Snead ML, Stupp SI. (2016) Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility. Nano Lett. 2016 May 11;16(5):3042-50. doi: 10.1021/acs.nanolett.6b00054. Epub 2016 Apr 12. PubMed PMID: 27070195; PubMed Central PMCID: PMC4948975.

  2. Huang Z, Newcomb CJ, Lei Y, Zhou Y, Bornstein P, Amendt BA, Stupp SI, Snead ML. (2015) Bioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration. Biomaterials. 2015 Aug;61:216-28. doi:10.1016/j.biomaterials.2015.05.035. PubMed PMID: 26004236; PubMed Central PMCID: PMC4467543.

  3. Zhou Y, Snead ML, Tamerler C. (2015) Bio-inspired hard-to-soft interface for implant integration to bone. Nanomedicine. 2015 Feb;11(2):431-4. doi: 10.1016/j.nano.2014.10.003. Epub 2014 Nov 22. PubMed PMID: 25461292; PubMed Central PMCID: PMC4330108.

  4. Huang Z, Newcomb CJ, Zhou Y, Lei YP, Bringas P Jr, Stupp SI, Snead ML. (2013) The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPα and c-Jun. Biomaterials. 2013 Apr;34(13):3303-14. doi: 10.1016/j.biomaterials.2013.01.054. Epub 2013 Feb 9. PubMed PMID: 23398885; PubMed Central PMCID: PMC3600413.

  5. Wen X, Cawthorn WP, Macdougald OA, Stupp SI, Snead ML, Zhou Y. (2011) The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression. Biomaterials. 2011 Sep;32(27):6478-86. Epub 2011 Jun 12. PubMed PMID: 21663957;PubMed Central PMCID: PMC3134126.

  6. Warotayanont R, Frenkel B, Snead ML, Zhou Y. (2009) Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway. Biochem Biophys Res Commun. 387(3):558-63. PubMed PMID: 19615979; PubMed Central PMCID: PMC2758297.

  7. Warotayanont R, Zhu D, Snead ML, Zhou Y. (2008) Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun. 367(1):1-6. PubMed PMID: 18086559; PubMed Central PMCID: PMC2276612.

  8. Zhou Y, Snead ML. (2008) Derivation of cranial neural crest-like cells from human embryonic stem cells. Biochem Biophys Res Commun. 376(3):542-7. PubMed PMID: 18804450; PubMed Central PMCID: PMC2574922.

  9. Xu Y, Zhou YL, Erickson RL, Macdougald OA, Snead ML. (2007) Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene. Biochem Biophys Res Commun. 354(1):56-61. PubMed PMID: 17210130; PubMed Central PMCID: PMC1831826.

  10. Xu Y, Zhou YL, Gonzalez FJ, Snead ML. (2007) CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo. J Biol Chem. 282(41):29882-9. PubMed PMID: 17704518.

  11. Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, Macdougald OA, Snead ML. (2006) NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene. J Biol Chem. 281(23):16090-8

  12. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. (2006) Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 74:57-115.

  13. Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L, Snead ML. (2006) Transcription factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene expression. Eur J Oral Sci. 114 Suppl 1:169-77; discussion 201-2, 381.

  14. Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. (2005) Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 62(9):1038-46.

  15. Zhang Y, Eberhard DA, Frantz GD, Dowd P, Wu TD, Zhou Y, Watanabe C, Luoh SM, Polakis P, Hillan KJ, Wood WI, Zhang Z. (2004) GEPIS--quantitative gene expression profiling in normal and cancer tissues. Bioinformatic. 20(15):2390-8.

  16. Zhou Y, Luoh SM, Zhang Y, Watanabe C, Wu TD, Ostland M, Wood WI, Zhang Z. (2003) Genome-wide Identification of Chromosomal Regions of Increased Tumor Expression by Transcriptome Analysis. Cancer Res. 63: 5781-5784

  17. Zhou YL, Lei Y, Snead ML (2000) Functional antagonism between Msx2 and CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene expression is mediated by protein-protein interaction. J Biol Chem 275:29066-75

  18. Zhou YL, Snead ML. (2000) Identification of CCAAT/enhancer-binding protein alpha as a transactivator of the mouse amelogenin gene. J Biol Chem;275(16):12273-80

  19. Ni ZM, Yi N, Zhou Y, Shi LJ. (1994) The characteristics of the spindle fiber attachment (SFA) enriched fraction from mouse nuclei. Acta Biologiae Experimentatis Sinica. 26: 297-305

  20. Wei Y, Ni ZM, Zhou Y, Wu L, Shi LJ. (1994) The study of metaphasic chromosome pellicle. Acta Biologiae Experimentatis Sinica;27(4):505-13