Center for Craniofacial Molecular Biology

Herman Ostrow School of Dentistry of USC

Janet Moradian-Oldak

CSA 148 - HSC 9062
Phone: (323) 442-1759
Fax: (323) 442-2981
joldak@usc.edu
website: oldaklab.usc.edu

Janet Moradian-Oldak, M.Sc., Ph.D.

Professor of Dentistry, Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA

Professor of Biomedical Sciences and Bioengineering, Dept. of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA

  • Ben Gurion University, Israel
    B.S.
    1984
    Chemistry

  • Weizmann Institute of Science, Israel
    M.Sc.
    1986
    Structural Chemistry

  • Weizmann Institute of Science, Israel
    Ph.D.
    1992
    Structural Biology

  • University of Southern California, USA
    Post Doc
    1992-95
    Enamel Protein Biochemistry

  • 2016 - - Weston Fellow Visiting Professor - Dept. Structural Biology. Weizmann Institute of Science, Rehovot, Israel
  • 2015 - 2016 - Interim Vice Chair - Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA
  • 2014 - present - Professor of Biomedical Sciences and Bioengineering - Dept. of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA
  • 2011 - present - Professor of Dentistry - Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA
  • 2007 - 2011 - Associate Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2003 - 2007 - Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1995 - 2002 - Research Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1992 - 1995 - Research Associate - Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 1983 - Chemical Analysis and Industrial Research - Development of Energy Sources
  • 2019 - Fellow of American Association for the Advancement of Science (AAAS)
  • 2019 - IADR Basic Research in Biological Mineralization Distinguished Scientist Award
  • 2017-2018 - Elected Chair- AAAS Dentistry Section
  • 2015 - GSK/ IADR Innovation in Oral Care Award
  • 2014 - USC Coulter Translational Research partnership Program Award
  • 2013-2014 - President, AADR Southern California
  • 2013- - Vice President, International Conference of Chemistry and Biology of Mineralized Tissues
  • 2012- - Member, Musculoskeletal Tissue Engineering Study Section, CSR, NIH, HHS
  • 2007-2010 - Co-Chair 10th International Conference on the Chemistry and Biology of Mineralized Tissues
  • 2007-2009 - NIDCR Standing Study Section, Special Grants Review Committee (SGRC)
  • 2007-2008 - President, Mineralized Tissue Group, IADR/AADR
  • 2007- - Associate Editor, Connective Tissue Research
  • 2006 - Journal of Dental Research Cover of the Year Award
  • 2004- - NIDCR Ad-Hoc Study Sections
  • 2003-2005 - Editorial Board, Journal of Dental Research
  • 2001 - NIH/NIDCR R01 DE13414, Maxtrix-Based Mineral (MBM) Enamel Biomimetics, Principal Investigator
  • 1998 - Invited speaker; Gordon Conference on Biomineralization
  • 1998 - Young Investigators Award, Sixth International Conference on the Chemistry and Biology of Mineralized Tissues, Vittel, France
  • 1997 - NIH/NIDCR R29 DE12350, Amelogeuin processing and control of crystal growth, Principal Investigator
  • 1996 - Ciba Foundation Bursary , Dental Enamel, Symposium #205

Active Grants


A Peptide-Based Biomineralization Strategy for Tooth Repair - Grant #1 R01 DE027632

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 02/01/2019-01/31/2023
  • Goal: The major goal of this project is to develop a technology that will effectively rebuild dental structures lost due to NCCL lesions and prevent dentin hypesensitivity.

Monetite-Apatite Phase Transformation for an Enamel-Like Restorative Material - Grant #1 R21 DE027529

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 03/15/2019-02/27/2021
  • Goal: The major goal of this exploratory/developmental research proposal is to explore a novel biomimetic calcium phosphate (CaP) composite material that will have an enamel-like structure and can be applied to restore posterior Class I cavities.

Maxtrix-Based Mineral (MBM) Enamel Biomimetics - Grant #2 R01 DE13414

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 05/01/2019-04/29/2023
  • Goal: The goal of this proposal is to advance our understanding of ameloblastin’s structure and function through a systematic investigation of its interactions with different targets. The long-term goal is to understand the general principles that apply to the formation of dental enamel and to develop biomimetic strategies for the fabrication of enamel-like materials in-vitro.

Completed Grants


Amelogenin Processing and its Correlation with Apatite Crystal - Grant #R29 DE 12350

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 04/01/1998-03/31/2003
  • Goal: The major goal of this project is to examine the hypothesis: Activity of “ameloprotease-I” correlates with the formation and maturation of enamel apatite crystals. Ameloprotease-I activation occurs in the extracellular matrix through proteolysis of its precursors. Amelogenin processing includes adsorption and dissociation of the substrate (amelogenin) and the proteinase (ameloprotease-I) onto apatite crystals.

The Kinetics of Mineralization of Teeth - Grant #Subaward R545271

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: SUNY at Buffalo / National Institute of Dental Research
  • Period: 05/15/2008-04/30/2013
  • Goal: The proposed research aims to improve understanding of mineralization and demineralization of teeth. The earliest nucleation events of mineralization during development of enamel, dentin and bone will be investigated at kinetic and molecular levels in solutions or at organic template surfaces.

Maxtrix-Based Mineral (MBM) Enamel Biomimetics - Grant #2 R56 DE13414

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/21/2018-04/30/2019
  • Goal: To advance our understanding of ameloblastin’s structure and function through a systematic investigation of its interactions with different targets. During the one year period under the R56 mechanism we will focus on portions of the in vitro and cell culture studies in aims I and II only. The long-term goal is to understand the general principles that apply to the formation of dental enamel and to develop biomimetic strategies for the fabrication of enamel-like materials in-vitro.

A New Strategy for Amelogenin Crystallization - Grant #5 R21 DE015332

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/01/2003-06/30/2005
  • Goal: The major goal of this project is to develop and characterize surfaces for amelogenin adsorption in a monomeric state, which will be used for its crystallization, using Optical Wavelength Light Spectroscopy (OWLS), Scanning Angle Reflectometry (SAR) and Ellipsometry; and to carry out crystallization trails of amelogenin on a series of substrates as active nucleant surfaces to obtain X-ray diffraction quality single crystals

Action and Function of MMP-20 during Enamel Formation - Grant #5 R01 DE015644

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/01/2005-06/30/2009
  • Goal: The major goal of this project is to advance our understanding of the mechanism of action and function of the matrix metalloproteinase-20 (enamelysin) during enamel Biomineralization.

Chitosan-amelogenin-based hydrogel for tooth enamel repair - Grant #

  • Principal Investigator: Janet Moradian-Oldak, Ph.D. and Jin Ho Phark, Ph.D.
  • Sponsor: Wallace Coulter Foundation
  • Period: 07/01/2014-06/30/2015
  • Goal: To develop a technology that prevents progression of tooth decay and preserves tooth structure. A gel that when applied on enamel surface in children and adults, halts early caries lesions (white spots) and rebuilds lost enamel.

Repairing Tooth Enamel with Chitosan-Amelogenin-Based Hydrogel - Grant #05515-00001

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: International Association for Dental Research
  • Period: 07/01/2015-06/30/2017
  • Goal: To develop a new technology (in the form of a hydrogel) that, when applied to affected enamel surfaces in children and adults, halts early caries lesions (white spots), rebuilds lost enamel due to erosion, preserves tooth structure, and prevents progression of tooth decay.

Intrinsically Disordered Proteins in Biomineralization - Grant #5 R01 DE020099

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 09/25/2009-08/31/2014
  • Goal: The long term objective of the proposed research is to advance understanding of the role of extracellular matrix protein fragmentation in enamel and dentin, with a focus on the analysis of folding and the degree of disorder in the secondary structures of key proteins and polypeptides.

Maxtrix-Based Mineral (MBM) Enamel Biomimetics - Grant #R01 DE013414

  • Principal Investigator: Janet Moradian-Oldak, Ph.D.
  • Sponsor: National Institutes of Health
  • Period: 08/01/2001-09/20/2018
  • Goal: The major goal of this project is to understand the general principles that apply to the formation of matrix-based mineral (MBM).

  1. Su J, Bapat RA, Visakan G, Moradian-Oldak J. (2020) An Evolutionarily Conserved Helix Mediates Ameloblastin-Cell Interaction. Journal of Dental Research. In Press.

  2. Mukherjee K, Visakan G, Phark JH, Moradian-Oldak J. (2020) Enhancing Collagen Mineralization with Amelogenin Peptide: Towards the Restoration of Dentin. ACS Biomater. Sci. Eng. 2020, 6, 4, 2251–2262

  3. Bapat RA, Moradian-Oldak J. (2019) Immunohistochemical Co-Localization of Amelogenin and Ameloblastin in Developing Enamel Matrix. Methods Mol Biol. 2019;1922:219-228. doi: 10.1007/978-1-4939-9012-2_22. PubMed PMID: 30838580.

  4. Su J, Bapat RA, Moradian-Oldak J. (2019) The Expression and Purification of Recombinant Mouse Ameloblastin in E. coli. Methods Mol Biol. 2019;1922:229-236.doi: 10.1007/978-1-4939-9012-2_23. PubMed PMID: 30838581.

  5. Mukherjee K, Ruan Q, Moradian-Oldak J. (2019) Peptide-Mediated Biomimetic Regrowth of Human Enamel In Situ. Methods Mol Biol. 2019;1922:129-138. doi: 10.1007/978-1-4939-9012-2_13. PubMed PMID: 30838571.

  6. Su J, Kegulian NC, Arun Bapat R, Moradian-Oldak J. (2019) Ameloblastin Binds to Phospholipid Bilayers via a Helix-Forming Motif within the Sequence Encoded by Exon 5. ACS Omega. 2019 Feb 28;4(2):4405-4416. doi: 10.1021/acsomega.8b03582. PubMed PMID: 30873509; PubMed Central PMCID: PMC6410667.

  7. Tao J, Fijneman A, Wan J, Prajapati S, Mukherjee K, Fernandez-Martinez A, Moradian-Oldak J, De Yoreo JJ. (2018) Control of Calcium Phosphate Nucleation and Transformation through Interactions of Enamelin and Amelogenin Exhibits the “Goldilocks Effect”. Cryst. Growth Des. 2018, 18, 7391−7400

  8. Mukherjee K, Ruan Q, Nutt S, Tao JH, De Yoreo JJ, Moradian-Oldak J. (2018) Peptide-Based Bioinspired Approach to Regrowing Multilayered Aprismatic Enamel. ACS Omega. 2018 Mar 31;3(3):2546-2557. doi: 10.1021/acsomega.7b02004. Epub 2018 Mar 2. PubMed PMID: 29623301; PubMed Central PMCID: PMC5879487.

  9. Prajapati S, Ruan Q, Mukherjee K, Nutt S, Moradian-Oldak J. (2018) The Presence of MMP-20 Reinforces Biomimetic Enamel Regrowth. J Dent Res. 2018 Jan;97(1):84-90. doi: 10.1177/0022034517728504. Epub 2017 Aug 28. PubMed PMID: 28846464; PubMed Central PMCID: PMC5755807.

  10. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. (2017) Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 Nov 22;9(11):e3. doi: 10.1038/ijos.2017.40. Review. PubMed PMID: 29165423; PubMed Central PMCID: PMC5775332.

  11. Ren D, Ruan Q, Tao J, Lo J, Nutt S, Moradian-Oldak J. (2016) Amelogenin affects brushite crystal morphology and promotes its phase transformation to monetite. Cryst Growth Des. 2016 Sep 7;16(9):4981-4990. doi: 10.1021/acs.cgd.6b00569. Epub 2016 Aug 5. PubMed PMID: 28808430; PubMed Central PMCID: PMC5553050.

  12. Ruan Q, Liberman D, Zhang Y, Ren D, Zhang Y, Nutt S, Moradian-Oldak J. (2016) Assembly of Layered Monetite-Chitosan Nanocomposite and Its Transition to Organized Hydroxyapatite. ACS Biomater Sci Eng. 2016 Jun 13;2(6):1049-1058. doi: 10.1021/acsbiomaterials.6b00164. Epub 2016 May 24. PubMed PMID: 28804756; PubMed Central PMCID: PMC5553052.

  13. Su J, Chandrababu KB, Moradian-Oldak J. (2016) Ameloblastin peptide encoded by exon 5 interacts with amelogenin N-terminus. Biochem Biophys Rep. 2016 Sep;7:26-32. PubMed PMID: 27725968; PubMed Central PMCID: PMC5055063.

  14. Mazumder P, Prajapati S, Bapat R, Moradian-Oldak J. (2016) Amelogenin-Ameloblastin Spatial Interaction around Maturing Enamel Rods. J Dent Res. 2016 Aug;95(9):1042-8. doi: 10.1177/0022034516645389. PubMed PMID: 27146703; PubMed Central PMCID: PMC4959624.

  15. Mukherjee K, Ruan Q, Liberman D, White SN, Moradian-Oldak J. (2016) Repairing human tooth enamel with leucine-rich amelogenin peptide–chitosan hydrogel. Journal of Materials Research / Volume 31 / Issue 05 / 2016, pp 556-563

  16. Ruan Q, Liberman D, Bapat R, Chandrababu KB, Phark JH, Moradian-Oldak J. (2016) Efficacy of amelogenin-chitosan hydrogel in biomimetic repair of human enamel in pH-cycling systems. J Biomed Eng Inform. 2016 Mar;2(1):119-128. PubMed PMID:27331142; PubMed Central PMCID: PMC4912123.

  17. Prajapati S, Tao J, Ruan Q, De Yoreo JJ, Moradian-Oldak J. (2016) Matrix metalloproteinase-20 mediates dental enamel biomineralization by preventing protein occlusion inside apatite crystals. Biomaterials. 2016 Jan;75:260-70. doi: 10.1016/j.biomaterials.2015.10.031. Epub 2015 Oct 22. PubMed PMID: 26513418; PubMed Central PMCID: PMC4654413.

  18. Bauskar A, Mack WJ, Mauris J, Argüeso P, Heur M, Nagel BA, Kolar GR, Gleave ME, Nakamura T, Kinoshita S, Moradian-Oldak J, Panjwani N, Pflugfelder SC, Wilson MR, Fini ME, Jeong S. (2015) Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015 Sep 24;10(9):e0138958. doi: 10.1371/journal.pone.0138958. eCollection 2015. PubMed PMID: 26402857; PubMed Central PMCID: PMC4581869.

  19. Lokappa SB, Chandrababu KB, Moradian-Oldak J. (2015) Tooth enamel protein amelogenin binds to ameloblast cell membrane-mimicking vesicles via its N-terminus. Biochem Biophys Res Commun. 2015 Aug 28;464(3):956-61. doi: 10.1016/j.bbrc.2015.07.082. Epub 2015 Jul 17. PubMed PMID: 26188506; PubMed Central PMCID: PMC4532586.

  20. Ruan Q, Moradian-Oldak J. (2015) Amelogenin and Enamel Biomimetics. J Mater Chem B Mater Biol Med. 2015;3:3112-3129. PubMed PMID: 26251723; PubMed Central PMCID: PMC4523244.

  21. Moshaverinia A, Chen C, Xu X, Ansari S, Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML, Shi S. (2015) Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. PubMed PMID: 26120294; PubMed Central PMCID: PMC4478611.

  22. Bekshe Lokappa S, Balakrishna Chandrababu K, Dutta K, Perovic I, Spencer Evans J, Moradian-Oldak J. (2015) Interactions of amelogenin with phospholipids. Biopolymers. 2015 Feb;103(2):96-108. doi: 10.1002/bip.22573. PubMed PMID: 25298002; PubMed Central PMCID: PMC4415992.

  23. Ruan Q, Siddiqah N, Li X, Nutt S, Moradian-Oldak J. (2014) Amelogenin-chitosan matrix for human enamel regrowth: effects of viscosity and supersaturation degree. Connect Tissue Res. 2014 Aug;55 Suppl 1:150-4. doi: 10.3109/03008207.2014.923856. PubMed PMID: 25158201; PubMed Central PMCID: PMC4402213.

  24. Mazumder P, Prajapati S, Lokappa SB, Gallon V, Moradian-Oldak J. (2014) Analysis of co-assembly and co-localization of ameloblastin and amelogenin. Front Physiol. 2014 Jul 25;5:274. doi: 10.3389/fphys.2014.00274. eCollection 2014. PubMed PMID: 25120489; PubMed Central PMCID: PMC4110739.

  25. Ruan Q, Moradian-Oldak J. (2014) Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface. J Vis Exp. 2014 Jul 10;(89). doi:10.3791/51606. PubMed PMID: 25046057; PubMed Central PMCID: PMC4214252. Video: http://www.jove.com/video/51606

  26. Chandrababu KB, Dutta K, Lokappa SB, Ndao M, Evans JS, Moradian-Oldak J. (2014) Structural adaptation of tooth enamel protein amelogenin in the presence of SDS micelles. Biopolymers. 2014 May;101(5):525-35. doi: 10.1002/bip.22415. PubMed PMID: 24114119; PubMed Central PMCID: PMC3947416.

  27. McGuire JD, Mousa AA, Zhang BJ, Todoki LS, Huffman NT, Chandrababu KB, Moradian-Oldak J, Keightley A, Wang Y, Walker MP, Gorski JP. (2014) Extracts of irradiated mature human tooth crowns contain MMP-20 protein and activity. J Dent. 2014 May;42(5):626-35. doi: 10.1016/j.jdent.2014.02.013. Epub 2014 Mar 4. PubMed PMID: 24607847; PubMed Central PMCID: PMC4326248.

  28. Ruan Q, Zhang Y, Yang X, Nutt S, Moradian-Oldak J. (2013) An amelogenin-chitosan matrix promotes assembly of an enamel-like layer with a dense interface. Acta Biomater. 2013 Jul;9(7):7289-97. doi: 10.1016/j.actbio.2013.04.004. Epub 2013 Apr 6. PubMed PMID: 23571002; PubMed Central PMCID: PMC3669649.

  29. Gallon V, Chen L, Yang X, Moradian-Oldak J. (2013) Localization and quantitative co-localization of enamelin with amelogenin. J Struct Biol. 2013 Aug;183(2):239-49. doi: 10.1016/j.jsb.2013.03.014. Epub 2013 Apr 4. PubMed PMID: 23563189; PubMed Central PMCID: PMC3737400.

  30. Bromley KM, Lakshminarayanan R, Thompson M, Lokappa SB, Gallon VA, Cho KR, Qiu SR, Moradian-Oldak J. (2012) Amelogenin processing by MMP-20 prevents protein occlusion inside calcite crystals. Cryst Growth Des. 2012 Oct 3;12(10):4897-4905. Epub 2012 Aug 23. PubMed PMID: 23226976; PubMed Central PMCID: PMC3513936.

  31. Moradian-Oldak J. (2012) Protein-mediated enamel mineralization. Front Biosci. 2012 Jun 1;17:1996-2023. Review. PubMed PMID: 22652761; PubMed Central PMCID: PMC3442115.

  32. Yang X, Fan D, Mattew S, Moradian-Oldak J. (2011) Amelogenin-enamelin association in phosphate-buffered saline. Eur J Oral Sci. 2011 Dec;119 Suppl 1:351-6. doi: 10.1111/j.1600-0722.2011.00916.x. PubMed PMID: 22243267; PubMed Central PMCID:PMC3270693.

  33. Chen CL, Bromley KM, Moradian-Oldak J, Deyoreo JJ. (2011) In situ AFM Study of Amelogenin Assembly and Disassembly Dynamics on Charged Surfaces Provides Insights on Matrix Protein Self-Assembly. J Am Chem Soc. 2011 Nov 2;133(43):17406-13. doi: 10.1021/ja206849c. Epub 2011 Oct 4. PubMed PMID:21916473; PubMed Central PMCID: PMC3427831.

  34. Bromley KM, Kiss AS, Lokappa SB, Lakshminarayanan R, Fan D, Ndao M, Evans JS, Moradian-Oldak J. (2011) Dissecting Amelogenin Protein Nanospheres: CHARACTERIZATION OF METASTABLE OLIGOMERS. J Biol Chem. 2011 Oct 7;286(40):34643-53. Epub 2011 Aug 12.PubMed PMID: 21840988; PubMed Central PMCID: PMC3186391.

  35. Lacruz RS, Smith CE, Smith SM, Hu P, Bringas P Jr, Sahin-Tóth M, Moradian-Oldak J, Paine ML. (2011) Chymotrypsin C (Caldecrin) Is Associated with Enamel Development. J Dent Res. 2011 Oct;90(10):1228-33. Epub 2011 Aug 9. PubMed PMID: 21828354; PubMed Central PMCID: PMC3173010.

  36. Friddle RW, Battle K, Trubetskoy V, Tao J, Salter EA, Moradian-Oldak J, De Yoreo JJ, Wierzbicki A. (2011) Single-molecule determination of the face-specific adsorption of Amelogenin s C-terminus on hydroxyapatite. Angew Chem Int Ed Engl. 2011 Aug 8;50(33):7541-5. doi: 10.1002/anie.201100181. Epub 2011 Jun 27. PubMed PMID: 21710666.

  37. Yang X, Sun Z, Ma R, Fan D, Moradian-Oldak J. (2011) Amelogenin "nanorods" formation during proteolysis by Mmp-20. J Struct Biol. 2011 Nov;176(2):220-8. Epub 2011 Aug 5. PubMed PMID: 21840397; PubMed Central PMCID: PMC3185149.

  38. Goldberg HA, Macdougall MB, Moradian-Oldak J. (2011) Preface. Cells Tissues Organs. 2011;194(2-4):90-1. Epub 2011 Jul 29. PubMed PMID: 21832828.

  39. Cho KR, Huang Y, Yu S, Yin S, Plomp M, Qiu SR, Lakshminarayanan R, Moradian-Oldak J, Sy MS, De Yoreo JJ. (2011) A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures. J Am Chem Soc. 2011 Jun 8;133(22):8586-93. Epub 2011 May 17. PubMed PMID: 21534611.

  40. Bromley KM, Lakshminarayanan R, Lei YP, Snead ML, Moradian-Oldak J. (2011) Folding, Assembly, and Aggregation of Recombinant Murine Amelogenins with T21I and P41T Point Mutations. Cells Tissues Organs. 2011;194(2-4):284-90. Epub 2011 May 2.PubMed PMID: 21540557; PubMed Central PMCID: PMC3178092.

  41. Fan D, Iijima M, Bromley KM, Yang X, Mathew S, Moradian-Oldak J. (2011) The Cooperation of Enamelin and Amelogenin in Controlling Octacalcium Phosphate Crystal Morphology. Cells Tissues Organs. 2011;194(2-4):194-8. Epub 2011 Apr 28. PubMed PMID: 21525716; PubMed Central PMCID: PMC3178077

  42. Ndao M, Dutta K, Bromley KM, Lakshminarayanan R, Sun Z, Rewari G, Moradian-Oldak J, Evans JS. (2011) Probing the self-association, intermolecular contacts, and folding propensity of amelogenin. Protein Sci. 2011 Apr;20(4):724-34. doi: 10.1002/pro.603. PubMed PMID: 21351181; PubMed Central PMCID: PMC3081550.

  43. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML,Moradian-Oldak J, Paine ML. (2011) Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18;6(3):e18028. PubMed PMID: 21437261; PubMed Central PMCID: PMC3060920.

  44. Iijima M, Fan D, Bromley KM, Sun Z, Moradian-Oldak J. (2010) Tooth enamel proteins enamelin and amelogenin cooperate to regulate the growth morphology of octacalcium phosphate crystals. Cryst Growth Des. 2010 Nov;10(11):4815-4822. PubMed PMID: 21483648; PubMed Central PMCID: PMC3072691.

  45. Laksminarayanan R, Bromley KM, Lei YP, Snead ML, Moradian-Oldak J. (2010) Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins. J Biol Chem. 2010 Dec 24;285(52):40593-603. Epub 2010 Oct 7. PubMed PMID: 20929860; PubMed Central PMCID: PMC3003358.

  46. Sun Z, Carpiaux W, Fan D, Fan Y, Lakshminarayanan R, Moradian-Oldak J. (2010) Apatite reduces amelogenin proteolysis by MMP-20 and KLK4 in vitro. J Dent Res. 2010 Apr;89(4):344-8. Epub 2010 Feb 16. PubMed PMID: 20160068; PubMed Central PMCID:PMC3318039.

  47. Yang X, Wang L, Qin Y, Sun Z, Henneman ZJ, Moradian-Oldak J, Nancollas GH. (2010) How amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite. J Phys Chem B. 114(6):2293-300. PubMed PMID: 20104924; PubMed Central PMCID: PMC2848079.

  48. Moradian-Oldak J. (2009) The Regeneration of Tooth Enamel. Dimens Dent Hyg. 2009 Aug;7(8):12-15. PubMed PMID: 20651953; PubMed Central PMCID: PMC2908039.

  49. Fan D, Du C, Sun Z, Lakshminarayanan R, Moradian-Oldak J. (2009) In vitro study on the interaction between the 32 kDa enamelin and amelogenin. J Struct Biol. 2009 Apr;166(1):88-94. PubMed PMID: 19263522; PubMed Central PMCID: PMC4507495.

  50. Fan Y, Sun Z, Moradian-Oldak J (2009) Effect of fluoride on the morphology of calcium phosphate crystals grown on acid etched human enamel. Caries Research. 43(2):132-6. PubMed PMID: 19321991; PubMed Central PMCID: PMC2814026.

  51. Delak K, Harcup C, Lakshminarayanan R, Sun Z, Fan Y, Moradian-Oldak J, Evans JS. (2009) The tooth enamel protein, porcine amelogenin, is an intrinsically disordered protein with an extended molecular configuration in the monomeric form. Biochemistry, 48(10):2272-2281. PubMed PMID: 19236004; PubMed Central PMCID: PMC2748245.

  52. Lakshminarayanan R, Yoon I, Hegde BG, Fan D, Du C, Moradian-Oldak J. (2009) Analysis of Secondary Structure and Self-Assembly of Amelogenin by Variable Temperature Circular Dichroism and Isothermal Titration Calorimetry. Proteins: Structure Function. Bioinformatics. 76(3):560-9. PubMed PMID: 19274734; PubMed Central PMCID: PMC2748104.

  53. Fan Y, Sun Z, Moradian-Oldak J. (2009) Controlled remineralization of enamel in the presence of amelogenin and fluoride. Biomaterials, 30(4):478-83. PubMed PMID: 18996587; PubMed Central PMCID: PMC2642519.

  54. Du C, Fan D, Sun Z, Fan Y, Lakshminarayanan R, Moradian-Oldak J. (2009) Immunogold Labeling of Amelogenin in Developing Porcine Enamel Revealed by Field Emission Scanning Electron Microscopy. Cells Tissues Organs, 189(1-4):207-11. PubMed PMID: 18701812; PubMed Central PMCID: PMC2633245.

  55. Fan D, Lakshminarayanan R, Moradian-Oldak J. (2008) The 32kDa enamelin undergoes conformational transitions upon calcium binding. J Struct Biol. 163(1):109-15. PubMed PMID: 18508280; PubMed Central PMCID: PMC2574573.

  56. Sun Z, Fan D, Fan Y, Du C, Moradian-Oldak J. (2008) Enamel Proteases Reduce Amelogenin-Apatite Binding. J. Den. Res. 87(12):1133-7. PubMed PMID: 19029081; PubMed Central PMCID: PMC2628463.

  57. Wang L, Guan X, Yin H, Moradian-Oldak J, Nancollas GH. (2008) Mimicking the self-organized microstructure of tooth enamel. J Phys Chem C Nanomater Interfaces. 112(15):5892-5899. PubMed PMID: 19169386; PubMed Central PMCID: PMC2630287.

  58. Fan Y, Sun Z, Wang R, Abbott C, Moradian-Oldak J. (2007) Enamel inspired nano-composite fabrication through amelogenin supramolecular assembly. Biomaterials. 2007 Jul;28(19):3034-42. PubMed PMID: 17382381; PubMed Central PMCID: PMC1995434.

  59. Lakshminarayanan R, Fan D, Du C, Moradian-Oldak J. (2007) The role of secondary structure in the entropically driven amelogenin self-assembly. Biophysical Journal 93, 3664-3674. PubMed PMID: 17704165; PubMed Central PMCID: PMC2072069.

  60. Moradian-Oldak J (2007) The emergence of "nanospheres" as basic structural components adopted by amelogenin. J Dent Res 86(6):487-90. PubMed PMID: 17525347.

  61. Gergely C, Szalontai B, Moradian-Oldak J, Cuisinier FJ. (2007) Polyelectrolyte-mediated adsorption of amelogenin monomers and nanospheres forming mono- or multilayers. Biomacromolecules. 2007 Jul;8(7):2228-36. Epub 2007 Jun 19. PubMed PMID: 17579474; PubMed Central PMCID: PMC2586669.

  62. Wang L, Guan X, Du C, Moradian-Oldak J, Nancollas GH. (2007) Amelogenin Promotes the Formation of Elongated Apatite Microstructures in a Controlled Crystallization System. J Phys Chem C Nanomater Interfaces. 2007 May 3;111(17):6398-6404. PubMed PMID: 20333260; PubMed Central PMCID: PMC2843430.

  63. Moradian-Oldak J, Du C, Falini G. (2006) On the formation of amelogenin microribbons. Eur J Oral Sci. 114 Suppl 1:289-96; discussion 327-9, 382.

  64. Iijima M, Du C, Abbott C, Doi Y, Moradian-Oldak J. (2006) Control of apatite crystal growth by the co-operative effect of a recombinant porcine amelogenin and fluoride. Eur J Oral Sci. 114 Suppl 1:304-7; discussion 327-9, 382. PubMed PMID: 16674703.

  65. Du C, Moradian-Oldak J. (2006) Tooth regeneration: challenges and opportunities for biomedical material research. Biomed Mater 1(1):R10-7 Review.

  66. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. (2006) Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 74:57-115.

  67. Sun Z, Ahsan MM, Wang H, Du C, Abbott C, Moradian-Oldak J. (2006) Assembly and processing of an engineered amelogenin proteolytic product (rP148). Eur J Oral Sci.;114 Suppl 1:59-63; discussion 93-5, 379-80. PubMed PMID: 16674664.

  68. Moradian-Oldak J, Wen HB, Schneider GB, Stanford CM. (2006) Tissue engineering strategies for the future generation of dental implants. Periodontol 2000. 41:157-76.

  69. Petta V, Moradian-Oldak J, Yannopoulos SN, Bouropoulos N. (2006) Dynamic light scattering study of an amelogenin gel-like matrix in vitro. Eur J Oral Sci. 114 Suppl 1:308-14; discussion 327-9, 382. PubMed PMID: 16674704.

  70. Moradian-Oldak J. & Goldberg M. (2005) Amelogenin supra-molecular assembly in vitro compared to the architecture of the forming enamel matrix. Cells Tissue Organs. 181:202-218.

  71. Du C, Falini G, Fermani S, Abbott C, Moradian-Oldak J. (2005) Supramolecular Assembly of Amelogenin Nanospheres into Birefringent Microribbons. Science, Vol 307, Issue 5714, 1450-1454

  72. Du C, Schneider GB, Zaharias R, Abbott C, Seabold D, Stanford C, Moradian-Oldak J. (2005) Apatite/amelogenin coating on titanium promotes osteogenic gene expression. J Dent Res. 84(11):1070-4.

  73. Iijima M, Moradian-Oldak J. (2005) Control of apatite crystal growth in a fluoride containing amelogenin-rich matrix. Biomaterials. 26(13):1595-603

  74. Iijima M, Moradian-Oldak J. (2004) Control of octacalacium phosphate and apatite crystal growth by amelogenin matrices. J. Mat. Chem. 14,2189-2199

  75. Iijima M, Moradian-Oldak J. (2004) Interactions of Amelogenins with Octacalcium Phosphate Crystal Faces Are Dose Dependent. Calcif Tissue Int. 74(6):522-31

  76. Bouropoulos N, Moradian-Oldak J. (2004) Induction of apatite by the cooperative effect of amelogenin and the 32-kDa enamelin. J Dent Res.;83(4):278-82.

  77. Bouropoulos N, Moradian-Oldak J. (2003) Analysis of Hydroxyapatite Surface Coverage by Amelogenin Nanospheres Following the Langmuir Model for Protein Adsorption. Calcif Tissue Int 72(5):599-603

  78. Moradian-Oldak J, Iijima M, Bouropoulos N, Wen HB. (2003) Assembly of amelogenin proteolytic products and control of octacalcium phosphate crystal morphology. Connect Tissue Res. 44 Suppl 1:58-64.

  79. Wen HB, Moradian-Oldak J. (2003) Modification of calcium-phosphate coatings on titanium by recombinant amelogenin. J Biomed Mater Res; 64A(3):483-490

  80. Wang L, Moradian-Oldak J. (2002) Assessment of Enamelysin (MMP-20) Selectivity to Three Peptide Bonds on Amelogenin Sequence. J Dent Res. 81(10):664-7

  81. Moradian-Oldak J, Gharakanian N, Jimenez I. (2002) Limited proteolysis of amelogenin: Toward understanding the proteolytic processes in enamel extracellular matrix. Connect Tissue Res. 43(2-3):450-5

  82. Iijima M, Moriwaki Y, Wen HB, Fincham AG, Moradian-Oldak J (2002) Elongated growth of octacalcium phosphate crystals in recombinant amelogenin gels under controlled ionic flow. J Dent Res 81: 69-73

  83. Moradian-Oldak J, Bouropoulos N, Wang L, Gharakhanian N. (2002) Analysis of self-assembly and Apatite binding properties of amelogenins lacking the hydrophiliv C-terminal. Matrix Biology 21: 197-205.

  84. Iijima M, Moriwaki1 Y, Takagi T, Moradian-Oldak J (2001) Effects of bovine amelogenins on the crystal morphology of octacalcium phosphate in a model system of tooth enamel formation. J Crystal growth , 222, 615-626.

  85. Moradian-Oldak J (2001) Amelogenins: Assembly, processing and control of crystal morphology. Matrix Biology, 20, 293-305.

  86. Moradian-Oldak J, Jimenez I, Maltby D, Fincham AG (2001) Controlled Proteolysis of Amelogenins Reveals Exposure of both Carboxy- and Amino-Terminal Regions. Biopolymers, 58, 606-616.

  87. Wen HB, Fincham AG, Moradian-Oldak J (2001) Progressive accretion of amelogenin molecules during nanospheres assembly revealed by atomic force microscopy. Matrix Biology 20, 387-395.

  88. Wen HB, Moradian-Oldak J, Zhong JP, Greenspan DC, Fincham AG (2000) Effects of amelogenin on the transforming surface microstructure of Bioglass in calcifying solution. J. Biomedical Material Res. 52(4), 762-773

  89. Wen HB, Moradian-Oldak J, Fincham AG (2000) Dose dependent modulation of octacalcium phosphate crystal habit by amelogenins. J Dent Res 79:1902-1906

  90. Moradian-Oldak J, Paine ML, Lei YP, Fincham AG, Snead ML (2000) Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct. Biol., 131, 27-37.

  91. Ravindranath MH, Moradian-Oldak J, Fincham AG (1999) Tyrosyl motif in amelogenins binds N- acetyl-D-Glucosamine. J. Biol. Chem. 274:2464-2471.

  92. Wen HB, Moradian-Oldak J, Leung W, Bringas P, Fincham AG (1999) Microstructures of an amelogenin gel matrix. J. Struct. Biol., 126, 42-51.

  93. Wen HB, Moradian-Oldak J, Fincham AG (1999) Modulation of apatite crystal growth on bioglass by recombinant amelogenin. Biomaterials., 20, 1717-1725.

  94. Fincham AG, Moradian-Oldak J, Simmer JP (1999) The structural biology of the developing dental enamel matrix. J. Struct. Biology., 126, 270-299.

  95. Lyaruu DM, Hu CC, Zhang C, Qian Q, Ryu OH, Moradian-Oldak J, Woltgens JH, Fincham AG, Simmer JP (1998) Derived protein and cDNA sequences of hamster amelogenin. Eur J Oral Sci 106, 299-307

  96. Fincham AG, Leung W, Tan J, Moradian-Oldak J (1998) Does amelogenin nanospheres assembly proceed through intermediately-sized structures? Connect Tissue Res 38: 237-240

  97. Moradian-Oldak J, Leung W, Tan J, Fincham AG (1998) Effect of apatite crystals on the activity of amelogenin degrading enzymes. Connect. Tissue Res. 39, 131-140.

  98. Tan J, Leung W, Moradian-Oldak J, Zeichner-David M, Fincham AG (1998) Quantitative analysis of amelogenin solubility. J. Dent. Res ,77(6), 1388-1396.

  99. Tan J, Leung W, Moradian-Oldak J, Zeichner-David M, Fincham AG (1998) The pH dependent amelogenin solubility and its biological significance. Connect Tissue Res. 38: 215-21

  100. Ryu OH, Hu CC, Zhang C, Qian Q, Moradian-Oldak J, Fincham AG (1998) Proteolytic Activity of Oppossum Tooth Extract. Eur. J. Oral Sci. , 106, 337-344.

  101. Moradian-Oldak J, Tan J, Fincham AG (1998) Interaction of Amelogenin with Hydroxyapatite Crystals; an Adherence Effect Through Amelogenion Molecular Self-Association. Biopolymers, 46, 225-238.

  102. Moradian-Oldak J, Leung W, Fincham AG (1998) Temperature and pH-dependent supramolecular self-assembly of amelogenin molecules: a dynamic light-scattering analysis. J. Struct. Biol. 122, 320-327.

  103. Fincham AG, Baehner R, Chai Y, Crowe DL, Fincham C, Iskander M., Landesman HM, Lee M, Luo W, Paine M, Pereira L, Moradian-Oldak J, Rosenblum A, Snead ML, Thompson P, Wuenschell CW, Zeichner-David M, Shuler CF (1997) Problem-based Learning at the University of Southern California School of Dentistry. J. Dent Edu , 61, 417-425.

  104. Hu CC, Zhang C, Qian Q, Ryu OH, Moradian-Oldak J, Fincham AG, Simmer JP (1996) Cloning, DNA sequence, and alternative splining of Opossum Amelogenin mRNAs. J. Dent. Res. 75 (10), 1728-1734.

  105. Fincham AG, Moradian-Oldak J (1996) A comparative mass spectrometric analyses of enamel matrix proteins from four different species suggest a common pathway of post-proteolytic processing. Connect Tiss Res, 35, 151-156.

  106. Moradian-Oldak J, Leung W, Simmer JP, Zeichner-David M, Fincham AG (1996) Identification of a novel proteinase "Ameloprotease I" responsible for complete degradation of amelogenin during enamel maturation. Biochem J. 318, 1015-1021.

  107. Moradian-Oldak J, Sarte PE, Fincham AG (1996) Description of Two Classes of Proteinases From Enamel Extracellular Matrix Cleaving A Recombinant Amelogenin. Connect. Tiss. Res., 35, 231-238.

  108. Moradian-Oldak J, Simmer JP, Lau EC, Diekwisch TG, Slavkin HC, Fincham AG (1995) A review on the aggregation properties of a recombinant amelogenin. Connect. Tiss. Res. , 32, (# 1-4), 125-130.

  109. Fincham AG, Moradian-Oldak J, Diekwisch TG, Layaruu DM, Wright JT, Bringas P, Slavkin HC (1995) Evidence for a amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. J. Struct. Biol. 115, 50-59.

  110. Fincham AG, Moradian-Oldak J (1995) Recent advances in amelogenin biochemistry. Connect. Tiss. Res. ,32, (# 1-4),119-124.

  111. Zeichner-David M, Diekwisch T, Fincham A, Lau E, MacDougall M, Moradian-Oldak J, Simmer J, Snead M, Slavkin HC. (1995) Control of ameloblast differentiation. Int J Dev Biol. 1995 Feb;39(1):69-92. Review. PubMed PMID: 7626423.

  112. Fincham AG, Moradian-Oldak J, Sarte PE (1994) Mass-Spectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus. Calcif. Tiss. Intl 55, 398-400.

  113. Fincham AG, Moradian-Oldak J, Simmer JP, Sarte PE, Lau EC, Diekwisch TG, Slavkin HC (1994) Self-Assembly of a recombinant amelogenin protein generates supramolecular structures. J. Struct. Biol. , 112, 103-109

  114. Furedi-Milhofer H, Moradian-Oldak J, Veis A, Weiner S, Mintz K, Addadi L (1994) Interactions of matrix proteins from mineralized tissues with octacalcium phosphate and carbonate apatite. Connect. Tissue Res. 30: 251-64.

  115. Moradian-Oldak J, Simmer JP, Lau EC, Sarte PE, Slavkin HC, Fincham AG (1994) Detection of monodisperse aggregates of a recombinant amelogenin by dynamic light scattering. Biopolymers, 34, 1339-1347.

  116. Moradian-Oldak J, Simmer JP, Sarte PE, Zeichner-David M, Fincham AG (1994) Specific cleavage of a recombinant murine amelogenin at the carboxy-terminal region by a proteinase fraction isolated from developoing bovine tooth enamel . Archs. oral Biol.,39, 647-656.

  117. Fincham AG, Moradian-Oldak J (1993) Amelogenin post-translational modification : Carboxy-terminal processing and the phosphorylation of bovine and porcine "TRAP" and "LRAP" amelogenins. Biochem. Biophys. Res. Comm. 197, 248-255.

  118. Moradian-Oldak J, Frolow F, Addadi L, Weiner S (1992) Interactions between acidic matrix macromolecules and calcium phosphate ester crystals; Relevance to carbonate apatite formation in biomineralization. Proc. R. Soc. Lond (B), 247, 47-55.

  119. Landis WJ, Moradian-Oldak J, Weiner S (1991) Topographic imaging of mineral and collagen in the calcifying turkey tendon. Connect. Tissue Res, 25, 181-196.

  120. Moradian-Oldak J, Weiner S, Addadi L, Landis WJ, Traub W (1991) Electron diffraction study of individual crystals of bone, mineralized tendon and synthetic carbonate apatite. Connect. Tiss. Res., 25, 219-228.

  121. Addadi L, Berman A, Moradian-Oldak J, Weiner S (1990) Tuning of crystal nucleation and growth by proteins: Molecular interactions at solid-liquid interfaces in biomineralization. Croatica Chimica Acta, 63, 539-544.

  122. Addadi L, Berman A, Moradian-Oldak J, Weiner S (1989) Structural and Stereochemical relations between acidic macromolecules of organic matrices and crystals. Connect. Tiss. Res., 21, 127-135.

  123. Addadi L, Moradian J, Shay E, Maroudas N, Weiner S (1987) A chemical model for the cooperation of sulfate and carboxylate in calcite crystal nucleation. Relevance to biomineralization. Proc. Nat. Acad. Sci. 84, 2732-2736.