Michael Paine

CSA 135 - HSC 9062
Phone: (323) 442-1728
Fax: (323) 442-2981
paine@usc.edu
website:

Michael Paine, B.Sc., B.D.S., Ph.D.

Director, Craniofacial Biology, Graduate Program, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

USC Associates Professor of Dentistry, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

Professor, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA

  • Macquarie University, Sydney, Australia
    B.Sc.
    1985
    Biology

  • University of Sydney, Sydney, Australia
    B.D.S.
    1988
    Dentistry

  • University of Sydney, Sydney, Australia
    Ph.D.
    1993
    Pathology

  • University of Southern California
    Certificate
    1999
    Periodontolgy

  • 2011 - present - Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2007 - present - Director - Craniofacial Biology, Graduate Program, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2006 - 2011 - Associate Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2004 - present - USC Associates Professor of Dentistry - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2003 - present - Medical Staff,Department of Surgery, Division of Dental Surgery - Childrens Hospital Los Angeles, California
  • 2001 - 2004 - Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 2000 - 2002 - Clinical Dentist - Part-time in the city of Whittier (California, USA).Practice limited to the diagnosis and treatment of periodontal disease and implant dentistry.
  • 1998 - 2001 - Research Assistant Professor - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1996 - 1998 - Research Associate - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1996 - - Research Assistant Professor, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1994 - 1996 - Research Associate, Center for Craniofacial Molecular Biology - Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1991 - 1992 - Visiting Dental Officer - Westmead Hospital, Australia
  • 1990 - 1991 - Clinical dentist - part-time in the city of Bondi Junction, Australia
  • 1989 - Clinical general - dentist full-time in the city of Orange (Australia) including part of the year assisting with minor oral and oro-facial surgical cases at Orange Base and Dudley Private Hospitals.
  • 2006 - University of Sydney Short Term Visiting Fellowship.
  • 1999 - The William J. Gies Award for the best paper published in the Journal of Dental Research in 1998 titled "Protein to protein interactions: Criteria defining the assembly of the enamel organic matrix".
  • 1998 - Outstanding Presentation Award, Ninth Intercity Periodontics Research Presentation, California Society of Periodontists.
  • 1996 - University of Southern California School of Dentistry Colby Scholarship.
  • 1995 - Young Investigator Award for the Fifth International Conference on the Chemistry and Biology of Mineralized Tissue, Kohler, Wisconsin.
  • 1993 - Sydney University Faculty of Medicine Traveling Fellowship - Thomas and Ethel Mary Ewing Scholarship in Medicine.
  • 1990 - National Health and Medical Research Council Dental Postgraduate Research Scholarship.

Molecular Mechanisms for Extracellular pH Control During Amelogenesis - Grant #R01 DE019629

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental Research
  • Period: 9/17/2009-06/30/2016
  • Goal: The major goal of this project is to investigate the hypothesis that the spatiotemporal expression profiles of AE2 and NBCe1 in ameloblast cells are highly regulated and are responsive to changing extracelluar pH conditions, and any failure in proper AE2 and NBCe1 activity will result in disruptions to the enamel prismatic structure.

Enamel Matrix Protein Interaction - Grant #R01 DE13404

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental Research
  • Period: 3/01/2000-03/31/2013
  • Goal: The major goal of this project is to understand the normal and abnormal enamel and DEJ formation that will allow investigators to pursue the creation of an enamel and DEJ biomimetic.

TIP39kDa and Tooth Formation - Grant #R01 DE14867

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental and Craniofacial Research
  • Period: 7/01/2003-06/30/2009
  • Goal: The major goal of this project was to identify a definitive function for TIP39kDa, and to explain the nature of the multiple mRNA isoforms observed for this protein in the enamel organ.

Doctoral and Post-doctoral Training in Craniofacial Biology (T90) - Grant #T90 DE021982

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental and Craniofacial Research
  • Period: 7/01/2011-6/30/2016
  • Goal: This grant supports education and training for a select cadre of scholars seeking either a formal PhD degree education or post-doctoral training (both DDS and PhD graduates) with a major focus on dental, orofacial and craniofacial health-related disease processes.

Doctoral and Post-doctoral Training in Craniofacial Biology - Grant #R90 DE022528

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental and Craniofacial Research
  • Period: 7/01/2011-6/30/2016
  • Goal: This grant supports education and post-doctoral training for foreign national post-doctoral scholars with a major focus on dental, orofacial and craniofacial health-related disease processes. Selected trainees must have both a dental degree and a PhD, or the equivalent degrees to qualify.

Sodium-Dependent Phosphate Transporter Function in Odontogenesis - Grant #R21 DE024704

  • Principal Investigator: Michael Paine, B.D.S., Ph.D.
  • Sponsor: National Institute of Dental and Craniofacial Research
  • Period: 03/01/2016-02/28/2018
  • Goal: The major goal of this project is to study phosphate ion import channels evident on dental cell membranes with the idea that even a fundamental understanding of phosphate transport in dental tissues will result in opportunities to develop better treatment options for caries and other dental diseases, that impact dental hard tissue health.
  1. Moshaverinia A, Chen C, Xu X, Ansari S, Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML, Shi S. (2015) Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. PubMed PMID: 26120294; PubMed Central PMCID: PMC4478611.

  2. Wen X, Lacruz RS, Paine ML. (2015) Dental and Cranial Pathologies in Mice Lacking the Cl(-) /H(+) -Exchanger ClC-7. Anat Rec (Hoboken). 2015 Aug;298(8):1502-8. doi:10.1002/ar.23118. Epub 2015 Feb 27. PubMed PMID: 25663454; PubMed Central PMCID: PMC4503507.

  3. Yin K, Hacia JG, Zhong Z, Paine ML. (2014) Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics. 2014 Nov 19;15:998. doi:10.1186/1471-2164-15-998. PubMed PMID: 25406666; PubMed Central PMCID:PMC4254193.

  4. Sarkar J, Simanian EJ, Tuggy SY, Bartlett JD, Snead ML, Sugiyama T, Paine ML. (2014) Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. Front Physiol. 2014 Jul 25;5:277. doi: 10.3389/fphys.2014.00277. eCollection 2014. PubMed PMID: 25120490; PubMed Central PMCID: PMC4110967.

  5. Jalali R, Guo J, Zandieh-Doulabi B, Bervoets TJ, Paine ML, Boron WF, Parker MD, Bijvelds MJ, Medina JF, DenBesten PK, Bronckers AL. (2014) NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. Cell Tissue Res. 2014 Jul 11. [Epub ahead of print] PubMed PMID: 25012520.

  6. Wen X, Kurtz I, Paine ML. (2014) Prevention of the disrupted enamel phenotype in slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. PLoS One. 2014 May 14;9(5):e97318. doi: 10.1371/journal.pone.0097318. eCollection 2014. PubMed PMID: 24828138; PubMed Central PMCID: PMC4020772.

  7. Wen X, Lacruz RS, Smith CE, Paine ML. (2014) Gene-expression profile and localization of Na+/K(+)-ATPase in rat enamel organ cells. Eur J Oral Sci. 2014 Feb;122(1):21-6. doi: 10.1111/eos.12106. Epub 2013 Dec 7. PubMed PMID: 24313748; PubMed Central PMCID: PMC4005357.

  8. Li X, Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA. (2014) A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014 Jan 1;23(1):194-208. doi: 10.1093/hmg/ddt411. Epub 2013 Aug 23. PubMed PMID: 23975681; PubMed Central PMCID: PMC3857954.

  9. Lacruz RS, de Castro JM, Martinón-Torres M, O Higgins P, Paine ML, Carbonell E, Arsuaga JL, Bromage TG. (2013) Facial morphogenesis of the earliest europeans. PLoS One. 2013 Jun 6;8(6):e65199. doi: 10.1371/journal.pone.0065199. Print 2013. PubMed PMID: 23762314; PubMed Central PMCID: PMC3675139.

  10. Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine ML. (2013) Adaptor protein complex 2 (AP-2) mediated, clathrin dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar;28(3):672-87. doi: 10.1002/jbmr.1779. PubMed PMID: 23044750; PubMed Central PMCID: PMC3562759.

  11. Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C. (2013) Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 2013 Apr;121(2):76-85. doi: 10.1111/eos.12020. Epub 2013 Feb 7. PubMed PMID: 23489896; PubMed Central PMCID: PMC3602929.

  12. Wen X, Paine ML. (2013) Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. BMC Res Notes. 2013 Jan 2;6:1. doi: 10.1186/1756-0500-6-1. PubMed PMID: 23281703; PubMed Central PMCID: PMC3556315.

  13. Lacruz RS, Smith CE, Kurtz I, Hubbard MJ, Paine ML. (2013) New Paradigms on the Transport Functions of Maturation-stage Ameloblasts. J Dent Res. 2013 Feb;92(2):122-9. doi: 10.1177/0022034512470954. Epub 2012 Dec 14. PubMed PMID:23242231; PubMed Central PMCID: PMC3545694.

  14. Lees JD, Robinson C, Shore RC, Paine ML, Brookes SJ. (2012) Cellular uptake and processing of enamel matrix derivative by human periodontal ligament fibroblasts. Arch Oral Biol. 2013 Apr;58(4):348-54. doi: 10.1016/j.archoralbio.2012.08.003.Epub 2012 Aug 29. PubMed PMID: 22939369; PubMed Central PMCID: PMC3587288.

  15. Hu P, Lacruz RS, Smith CE, Smith SM, Kurtz I, Paine ML. (2012) Expression of the Sodium/Calcium/Potassium Exchanger, NCKX4, in Ameloblasts. Cells Tissues Organs. Cells Tissues Organs. 2012;196(6):501-9. doi: 10.1159/000337493. Epub 2012 Jun 5. PubMed PMID:22677781; PubMed Central PMCID: PMC3535175.

  16. Lacruz RS, Hacia JG, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. (2012) The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun;27(3):237-45. doi: 10.1177/0748730412442830. PubMed PMID: 22653892; PubMed Central PMCID: PMC3511783.

  17. Lacruz RS, Nakayama Y, Holcroft J, Nguyen V, Somogyi-Ganss E, Snead ML, White SN, Paine ML, Ganss B. (2012) Targeted overexpression of amelotin disrupts the microstructure of dental enamel. PLoS One. 2012;7(4):e35200. Epub 2012 Apr 23.PubMed PMID: 22539960; PubMed Central PMCID: PMC3335167.

  18. Lacruz RS, Smith CE, Bringas Jr P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. (2012) Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May;227(5):2264-75. doi: 10.1002/jcp.22965. PubMed PMID: 21809343; PubMed Central PMCID: PMC3243804.

  19. Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P Jr, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML. (2012) Requirements for ion and solute transport, and pH regulation, during enamel maturation. J Cell Physiol. 2012 Apr;227(4):1776-85. doi: 10.1002/jcp.22911. PubMed PMID: 21732355; PubMed Central PMCID: PMC3373187.

  20. Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML. (2011) Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci. 2011 Dec;119 Suppl 1:149-57. doi: 10.1111/j.1600-0722.2011.00881.x. PubMed PMID: 22243241; PubMed Central PMCID: PMC3286129.

  21. Snead CM, Smith SM, Sadeghein N, Lacruz RS, Hu P, Kurtz I, Paine ML. (2011) Identification of a pH-responsive DNA region upstream of the transcription start site of human NBCe1-B. Eur J Oral Sci. 2011 Dec;119 Suppl 1:136-41. doi:10.1111/j.1600-0722.2011.00867.x. PubMed PMID: 22243239; PubMed Central PMCID: PMC3374727.

  22. Tamburstuen MV, Snead ML, Reseland JE, Paine ML, Lyngstadaas SP. (2011) Ameloblastin upstream region contains structural elements regulating transcriptional activity in a stromal cell line derived from bone marrow. Eur J Oral Sci. 2011 Dec;119 Suppl 1:286-92. doi: 10.1111/j.1600-0722.2011.00910.x. PubMed PMID: 22243258; PubMed Central PMCID: PMC3370392.

  23. Lacruz RS, Smith CE, Smith SM, Hu P, Bringas P Jr, Sahin-Tóth M, Moradian-Oldak J, Paine ML. (2011) Chymotrypsin C (Caldecrin) Is Associated with Enamel Development. J Dent Res. 2011 Oct;90(10):1228-33. Epub 2011 Aug 9. PubMed PMID: 21828354; PubMed Central PMCID: PMC3173010.

  24. Chang EH, Lacruz RS, Bromage TG, Bringas P, Welsh MJ, Zabner J, Paine ML. (2011) Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011;194(2-4):249-54. Epub 2011 Apr 28. PubMed PMID: 21525720; PubMed Central PMCID: PMC3178086.

  25. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML,Moradian-Oldak J, Paine ML. (2011) Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18;6(3):e18028. PubMed PMID: 21437261; PubMed Central PMCID: PMC3060920.

  26. Snead ML, Zhu DH, Lei Y, Luo W, Bringas PO Jr, Sucov HM, Rauth RJ, Paine ML, White SN. (2011) A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr;32(12):3151-7. Epub 2011 Feb 5. PubMed PMID: 21295848; PubMed Central PMCID: PMC3045652.

  27. Lacruz RS, Nanci A, White SN, Wen X, Wang H, Zalzal SF, Luong VQ, Schuetter VL, Conti PS, Kurtz I, Paine ML. (2010) The Sodium Bicarbonate Cotransporter (NBCe1) Is Essential for Normal Development of Mouse Dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8. Epub 2010 Jun 6. PubMed PMID: 20529845; PubMed Central PMCID: PMC2915679.

  28. Lacruz RS, Hilvo M, Kurtz I, Paine ML. (2010) A survey of carbonic anhydrase mRNA expression in enamel cells. Biochem Biophys Res Commun. 393(4):883-7. PubMed PMID: 20175995; PubMed Central PMCID: PMC2843801.

  29. Lacruz RS, Nanci A, Kurtz I, Wright JT, Paine ML. (2010) Regulation of pH During Amelogenesis. Calcif Tissue Int. 86(2):91-103. PubMed PMID: 20016979; PubMed Central PMCID: PMC2809306.

  30. Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine ML, Lacruz RS, Snead ML, White SN. (2009) Dental enamel: genes define biomechanics. J Calif Dent Assoc. 37(12):863-8. PubMed PMID:20066874; PubMed Central PMCID: PMC2825347.

  31. Tannukit S, Crabb TL, Hertel KJ, Wen X, Jans DA, Paine ML. (2009) Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Biochem Biophys Res Commun. 390(3):1044-50. PubMed PMID: 19857462; PubMed Central PMCID: PMC2787706.

  32. Lyngstadaas SP, Wohlfahrt JC, Brookes SJ, Paine ML, Snead ML, Reseland JE. (2009) Enamel matrix proteins; old molecules for new applications. Orthod Craniofac Res. 12(3):243-53. PubMed PMID: 19627527; PubMed Central PMCID: PMC2825346.

  33. Paine ML, Snead ML, Wang HJ, Abuladze N, Pushkin A, Liu W, Kao LY, Wall SM, Kim YH, Kurtz I. (2008) Role of NBCe1 and AE2 in secretory ameloblasts. J Dent Res. 87(4):391-5. PubMed PMID: 18362326; PubMed Central PMCID: PMC2504252.

  34. Tannukit S, Wen X, Wang H, Paine ML. (2008) TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization. Int J Mol Sci. 9(8):1504-1514. PubMed PMID: 19122807; PubMed Central PMCID: PMC2605624.

  35. Wen X, Tannukit S, Paine ML. (2008) TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly. Int J Mol Sci., 9(11), 2105-2113. PubMed PMID: 19165350; PubMed Central PMCID: PMC2629433.

  36. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML. (2008) Biglycan Overexpression on Tooth Enamel Formation in Transgenic Mice. Anat Rec (Hoboken). 291(10):1246-53. PubMed PMID: 18727043; PubMed Central PMCID: PMC2562349.

  37. White SN, Paine ML, Ngan AY, Miklus VG, Luo W, Wang H, Snead ML. (2007) Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem. 282(8):5340-5. PubMed PMID: 17189271.

  38. Zou Y, Wang H, Shapiro JL, Okamoto CT, Brookes SJ, Lyngstadaas SP, Snead ML, Paine ML. (2007) Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15;408(3):347-54. PubMed PMID: 17708745; PubMed Central PMCID: PMC2267358.

  39. Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML. (2007) Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci. 64(2):244-56. PubMed PMID: 17187173.

  40. Tarasevich BJ, Howard CJ, Larson JL, Snead ML, Simmer JP, Paine M, Shaw WJ. (2007) The nucleation and growth of calcium phosphate by amelogenin. J Cryst Growth. 2007 Jun 15;304(2):407-415. PubMed PMID: 19079557; PubMed Central PMCID: PMC2597808.

  41. Swanson EC, Fong HK, Foster BL, Paine ML, Gibson CW, Snead ML, Somerman MJ. (2006) Amelogenins regulate expression of genes associated with cementoblasts in vitro. Eur J Oral Sci. 114 Suppl 1:239-43; discussion 254-6, 381-2. PubMed PMID: 16674692.

  42. Shapiro JL, Wang H, Wen X, Tannukit S, Paine ML. (2006) An amelogenin minigene to study alternative splicing. DNA Cell Biol. 25(1):1-5. PubMed PMID: 16405395.

  43. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. (2006) Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 74:57-115.

  44. Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML. (2006) Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000. 41:123-35. Review.

  45. Zhu D, Paine ML, Luo W, Bringas P Jr, Snead ML. (2006) Altering biomineralization by protein design. J Biol Chem. 281(30):21173-82. PubMed PMID: 16707492.

  46. Wang HJ, Tannukit S, Wen X, Shapiro JL, Snead ML, Paine ML. (2006) Using the yeast two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide and for tuftelin-interacting protein 11. Eur J Oral Sci. 114 Suppl 1:276-9.

  47. Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. (2005) Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 62(9):1038-46.

  48. White SN, Miklus VG, Chang PP, Caputo AA, Fong H, Sarikaya M, Luo W, Paine ML, Snead ML. (2005) Controlled failure mechanisms toughen the dentino-enamel junction zone. J Prosthet Dent. 94(4):330-5.

  49. Yin Y, Huang J, Paine ML, Reinhold VN, Chasteen ND. (2005) Structural Characterization of the Major Extrapallial Fluid Protein of the Mollusc Mytilus edulis: Implications for Function. Biochemistry. 44(31):10720-31.

  50. Paine ML, Luo W, Wang HJ, Bringas P Jr, Ngan AY, Miklus VG, Zhu DH, Macdougall M, White SN, Snead ML. (2005) Dentin sialoprotein and dentin phosphoprotein over-expression during amelogenesis. J Biol Chem. 280(36):31991-8

  51. Paine ML, Snead ML. (2005) Tooth developmental biology: disruptions to enamel-matrix assembly and its impact on biomineralization. Orthod Craniofac Res. 8(4):239-51. Review.

  52. Wang H, Tannukit S, Zhu D, Snead ML, Paine ML. (2005) Enamel matrix protein interactions. J Bone Miner Res. 20(6):1032-40.

  53. Shaw WJ, Campbell AA, Paine ML, Snead ML. (2004) The COOH Terminus of the Amelogenin, LRAP, Is Oriented Next to the Hydroxyapatite Surface. J Biol Chem. 279(39):40263-6

  54. Paine ML, Zhu DH, Luo W, Snead ML. (2004) Overexpression of TRAP in the Enamel Matrix Does Not Alter the Enamel Structural Hierarchy. Cells Tissues Organs, 176:7-16.

  55. Luo W, Wen X, Wang HJ, MacDougall M, Snead ML, Paine ML. (2004) In vivo overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs. 177(4):212-20.

  56. Paine ML, Paine CT, Machin GA. (2004) Hair whorls and monozygosity. J Invest Dermatol. 2004 Apr;122(4):1057-8. PubMed PMID: 15102099.

  57. Fong H, White SN, Paine ML, Luo W, Snead ML, Sarikaya M. (2003) Enamel structure properties controlled by engineered proteins in transgenic mice. J Bone Miner Res. 18(11):2052-9

  58. Paine ML, Luo W, Zhu DH, Bringas P Jr, Snead ML. (2003) Functional domains for amelogenin revealed by compound genetic defects. J Bone Miner Res;18(3):466-72

  59. Paine ML, Wang HJ and Snead ML. (2003) Amelogenin Self-Assembly and the Role of the Proline Located within the Carboxyl-Teleopeptide. Connective Tissue Research, 44(Suppl. 1): 52-57.

  60. Paine ML, Wang HJ, Luo W, Krebsbach PH, Snead ML. (2003) A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin over-expression. J Biol Chem 278:19447-52

  61. Dunglas C, Septier D, Paine ML, Zhu DH, Snead ML, Goldberg M. (2002) Ultrastructure of Forming Enamel in Mouse Bearing a Transgene That Disrupts the Amelogenin Self-Assembly Domains. Calcif Tissue Int 71(2):155-66

  62. Paine ML, Lei YP, Dickerson K, Snead ML. (2002) Altered Amelogenin Self-assembly Based on Mutations Observed in Human X-linked Amelogenesis Imperfecta (AIH1). J Biol Chem 10;277(19):17112-6

  63. Paine ML, Hansen DJ. (2002) Factors influencing children to self-disclose sexual abuse. Clin Psychol Rev. 2002 Mar;22(2):271-95. Review. PubMed PMID: 11806022.

  64. White SN, Luo W, Paine ML, Fong H, Sarikaya M, Snead ML (2001) Biological organization of hydroxyapatite crystallites into a fibrous continuum toughens and controls anisotropy in human enamel. J Dent Res 2001 Jan;80(1):321-326

  65. Paine ML, White SN, Luo W, Fong H, Sarikaya M, Snead ML (2001) Regulated gene expression dictates enamel structure and tooth function. Matrix Biol 2001 Sep;20(5-6):273-92

  66. Moradian-Oldak J, Paine ML, Lei YP, Fincham AG, Snead ML (2000) Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct Biol 2000 Jul;131(1):27-37

  67. Paine ML, Zhu DH, Luo W, Bringas P Jr, Goldberg M, White SN, Lei YP, Sarikaya M, Fong HK, Snead ML (2000) Enamel biomineralization defects result from alterations to amelogenin self-assembly. J Struct Biol 132(3):191-200

  68. Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML (2000). A tuftelin-interacting protein (2000) localizes to the apical secretory pole of mouse ameloblasts. J. Biol. Chem. 21;275(29):22284-92.

  69. Paine ML, Krebsbach PH, Chen LS, Paine CT, Yamada Y, Deutsch D, Snead ML. (1998) Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix. J Dent Res. 1998 Mar;77(3):496-502. PubMed PMID: 9496923.

  70. Paine CT, Paine ML, Snead ML (1998) Identification of tuftelin and amelogenin-interacting proteins using the yeast two-hybrid system. Connect Tissue Res 1998;38(1-4):257-267

  71. Paine ML, Slots J, Rich SK (1998) Fluoride use in periodontal therapy: A review of the literature. Journal of the American Dental Association, 129, 69-77.

  72. Paine ML, Krebsbach PH, Chen LS, Paine CT, Yamada Y, Deutsch D, Snead ML (1998) Protein to protein interactions: Criteria defining the assembly of the enamel organic matrix. Journal of Dental Research, 77, 496-502.

  73. Snead ML, Paine ML, Luo W, Zhu DH, Yoshida B, Lei YP, Chen LS, Paine CT, Burstein JM, Jitpukdeebudintra S, White SN, Bringas P Jr (1998) Transgene animal model for protein expression and accumulation into forming enamel. Connect Tissue Res 1998;38(1-4):279-286

  74. Paine ML, Snead ML (1997) Protein interactions during assembly of the organic extracellular matrix. Journal of Bone and Mineral Research, 12, 221-227.

  75. Paine ML, Gibbins JR, Kefford RF (1997) Non-coexpression of collagenase and transin in malignant epithelial cells. International Journal of Oncology, 10, 615-618.

  76. Paine ML, Deutsch D, Snead ML (1997) Carboxyl-region of tuftelin mediates self-assembly. Connective Tissue Research, 35, 157-161.

  77. Fincham AG, Baehner R, Chai Y, Crowe DL, Fincham C, Iskander M, Landesman HM, Lee M, Luo W, Paine M, Pereira L, Moradian-Oldak J, Rosenblum A, Snead ML, Thompson P, Wuenschell C, Zeichner-David M, Shuler CF (1997) Problem-based learning at the University of Southern California School of Dentistry. Journal of Dental Education, 61, 417-425.

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