Qiang Shao

CSC 121E, HSC 9062
Phone: (323) 442-0282
Fax: (323) 442-2981

Qiang Shao, Ph.D.

Postdoctoral Scholar - Research Associate, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA

  • Shenyang Agricultural University, China

  • China Agricultural University, China
    Biochemistry & Molecular Biology

  • 2017 - present - Postdoctoral Scholar - Research Associate - Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 2015 - 2017 - Postdoctoral Fellow - Dept. of Genetics, Dept. of Biochemistry & Molecular Biology, University of Georgia
  1. Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Apr 1;34(7-8):580-597. doi: 10.1101/gad.332494.119. Epub 2020 Feb 27. PubMed PMID: 32115408; PubMed Central PMCID: PMC7111266.

  2. Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, Luo J, Lee JK, Liang C, Chen JF. (2019) C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. 2019 Dec 26:1-16. doi: 10.1080/15548627.2019.1703353. [Epub ahead of print] PubMed PMID: 31847700.

  3. Shao Q, Liang C, Chang Q, Zhang W, Yang M, Chen JF. (2019) C9orf72 deficiency promotes motor deficitsof a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathol Commun. 2019 Mar 4;7(1):32. doi: 10.1186/s40478-019-0685-7. PubMed PMID: 30832726; PubMed Central PMCID: PMC6398253.

  4. Herrlinger S, Shao Q, Yang M, Chang Q, Liu Y, Pan X, Yin H, Xie LW, Chen JF. (2019) Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice. Development. 2019 May 28;146(10). pii: dev173765. doi: 10.1242/dev.173765. PubMed PMID: 31064784; PubMed Central PMCID: PMC6550015.

  5. Zhang W, Yang SL, Yang M, Herrlinger S, Shao Q, Collar JL, Fierro E, Shi Y, Liu A, Lu H, Herring BE, Guo ML, Buch S, Zhao Z, Xu J, Lu Z, Chen JF. (2019) Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nat Commun. 2019 Jun 13;10(1):2612. doi: 10.1038/s41467-019-10497-2. PubMed PMID: 31197141; PubMed Central PMCID: PMC6565620.

  6. Liang C, Shao Q, Zhang W, Yang M, Chang Q, Chen R, Chen JF. (2019) Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Hum Mol Genet. 2019 Oct 18. pii: ddz230. doi: 10.1093/hmg/ddz230. [Epub ahead of print] PubMed PMID: 31625563.

  7. Herrlinger SA, Shao Q, Ma L, Brindley M, Chen JF. (2018) Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult. J Vis Exp. 2018 Apr 26;(134). doi:10.3791/56486. PubMed PMID: 29757270; PubMed Central PMCID: PMC6035874.

  8. Dong K, Guo X, Chen W, Hsu AC, Shao Q, Chen JF, Chen SY. (2018) Mesenchyme Homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. J Biol Chem. 2018 Jun 1;293(22):8712-8719. doi: 10.1074/jbc.RA118.002350. Epub 2018 Apr 20. PubMed PMID: 29678882; PubMed Central PMCID: PMC5986210.

  9. Wang YC, Chuang YH, Shao Q, Chen JF, Chen SY. (2018) Brain cytoplasmic RNA 1 suppresses smooth muscle differentiation and vascular development in mice. J Biol Chem. 2018 Apr 13;293(15):5668-5678. doi: 10.1074/jbc.RA117.001578. Epub 2018 Feb 21. PubMed PMID: 29467228; PubMed Central PMCID: PMC5900757.

  10. Shao Q, Herrlinger S, Zhu YN, Yang M, Goodfellow F, Stice SL, Qi XP, Brindley MA, Chen JF. (2017) The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus. Development. 2017 Nov 15;144(22):4114-4124. doi: 10.1242/dev.156752. Epub 2017 Oct 9. PubMed PMID: 28993398; PubMed Central PMCID: PMC5719247.

  11. Guo Q, Shao Q, Xu W, Rui L, Sumi R, Eguchi F, Li Z. (2017) Immunomodulatory and Anti-IBDV Activities of the Polysaccharide AEX from Coccomyxa gloeobotrydiformis. Mar Drugs. 2017 Feb 10;15(2). pii: E36. doi: 10.3390/md15020036. PubMed PMID:28208594; PubMed Central PMCID: PMC5334616.

  12. Shao Q, Herrlinger S, Yang SL, Lai F, Moore JM, Brindley MA, Chen JF. (2016) Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development. 2016 Nov 15;143(22):4127-4136. Epub 2016 Oct 11. PubMed PMID: 27729407; PubMed Central PMCID: PMC5117220.

  13. Zheng P, Shao Q, Diao X, Li Z, Han Q. (2016) Expression of stem cell pluripotency factors during regeneration in the earthworm Eisenia foetida. Gene. 2016 Jan 1;575(1):58-65. doi: 10.1016/j.gene.2015.08.034. Epub 2015 Aug 20. PubMed PMID:26299657.

  14. Yu X, Rui L, Shao Q, Liu H, Lu Y, Zhang Y, Li Z. (2015) Changes of CD4+CD25+ cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences. Viruses. 2015 Mar 20;7(3):1357-72. doi:10.3390/v7031357. PubMed PMID: 25803101; PubMed Central PMCID: PMC4379575.

  15. Shao Q, Xu W, Guo Q, Yan L, Rui L, Liu J, Zhao Y, Li Z. (2015) RIG-I from waterfowl and mammals differ in their abilities to induce antiviral responses against influenza A viruses. J Gen Virol. 2015 Feb;96(Pt 2):277-87. doi:10.1099/vir.0.069914-0. Epub 2014 Nov 4. PubMed PMID: 25371516.

  16. Xu W, Shao Q, Zang Y, Guo Q, Zhang Y, Li Z. (2015) Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV. Viruses. 2015 Jul 22;7(7):4131-51. doi:10.3390/v7072813. PubMed PMID: 26205406; PubMed Central PMCID: PMC4517142.

  17. Shao Q, Guo Q, Xu Wp, Li Z, Zhao Tt. (2015) Specific Inhibitory Effect of κ-Carrageenan Polysaccharide on Swine Pandemic 2009 H1N1 Influenza Virus. PLoS One. 2015 May 13;10(5):e0126577. doi: 10.1371/journal.pone.0126577. eCollection 2015. PubMed PMID: 25969984; PubMed Central PMCID: PMC4430168.

  18. Shao Q, Xu W, Yan L, Liu J, Rui L, Xiao X, Yu X, Lu Y, Li Z. (2014) Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells. Virus Res. 2014 Oct 13;191:184-91. doi:10.1016/j.virusres.2014.07.028. Epub 2014 Aug 12. PubMed PMID: 25128465.

  19. Zhang W, Rui L, Zhang J, Yu X, Yuan F, Yan L, Zhang Z, Wan Z, Shao Q, Qi C, Li Z. (2013) Production of chimeras between the Chinese soft-shelled turtle and Peking duck through transfer of early blastoderm cells. J Exp Biol. 2013 May 15;216(Pt10):1786-92. doi: 10.1242/jeb.072843. Epub 2013 Jan 24. PubMed PMID: 23348946.

  20. Zhang Z, Sun P, Yu F, Yan L, Yuan F, Zhang W, Wang T, Wan Z, Shao Q, Li Z. (2012) Transgenic quail production by microinjection of lentiviral vector into the early embryo blood vessels. PLoS One. 2012;7(12):e50817. doi: 10.1371/journal.pone.0050817. Epub 2012 Dec 12. PubMed PMID: 23251391; PubMed Central PMCID: PMC3520935.